Crosstalk between the Notch signaling pathway and long non-coding RNAs
Crosstalk between the Notch signaling pathway and long non-coding RNAs
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DOI：
10.1016/j.canlet.2018.01.070
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发表时间：
2018-01-01
期刊：
影响因子：
9.7
通讯作者：
Pichler, Martin
中科院分区：
文献类型：
--
作者：
Reicher, Andreas;Fosselteder, Johannes;Pichler, Martin
Notch信号通路在细胞发育中起关键作用，并通过从根本上影响细胞分化、增殖或迁移等过程而参与癌症的发生和发展。该通路受多个阶段的调控，根据细胞环境或信号剂量产生不同的结果。最近的研究表明，长非编码RNAs(Long Non-Coding RNAs，LncRNAs)是一类在许多癌症中失控的非编码RNAs，通过在转录或转录后水平上调节受体或配体的表达，参与调节Notch途径的活性。LncRNAs也是Notch信号的下游靶点，其中一些Notch诱导的LncRNAs已被报道为其致癌效应的诱导者。Notch信号和LncRNAs之间的这种相互作用使这些分子成为Notch信号活性的潜在生物标志物，并在未来成为基于RNA的有趣的治疗性靶标。(C)2018爱思唯尔B.V.保留所有权利。
The Notch signaling pathway has a key role in cellular development and is involved in initiation and progression of cancer by fundamentally influencing cellular processes such as differentiation, proliferation or migration. The pathway is regulated on many stages, generating diverse outcomes depending on cellular context or signaling dose. Recent studies suggest that long non-coding RNAs (lncRNAs), a class of non-coding RNAs deregulated in many cancers, are involved in regulating the Notch pathway activity by modulating the expression of receptors or ligands on transcriptional or posttranscriptional levels. LncRNAs are also downstream targets of Notch signaling and some of these Notch-induced lncRNAs have been reported to be inducers of its oncogenic effects. This cross-talk between Notch signaling and lncRNAs makes those molecules potential biomarkers for Notch signaling activity and interesting therapeutic RNA-based targets in the future. (C) 2018 Elsevier B.V. All rights reserved.