Cutaneous disease resembling mycosis fungoides in HIV-infected patients whose skin and blood cells also harbor proviral HTLV type I.
Cutaneous disease resembling mycosis fungoides in HIV-infected patients whose skin and blood cells also harbor proviral HTLV type I.
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HIV 感染者的皮肤疾病类似于蕈样肉芽肿，其皮肤和血细胞也含有前病毒 HTLV I 型。
DOI：
10.1089/aid.1994.10.1173
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发表时间：
1994
影响因子：
1.5
通讯作者：
Friedman-Kien,AE
中科院分区：
文献类型：
--
作者：
Zucker-Franklin,D;Pancake,BA;Friedman-Kien,AE
两名淋巴细胞计数<50的同性恋HIV感染患者表现为强烈的尿道炎、色素沉着和皮肤病变，临床上提示皮肤T细胞淋巴瘤、蕈样肉芽肿。在光学显微镜下，由于淋巴细胞浸润稀疏，皮肤活检难以解释。然而，电子显微镜显示外周血和皮肤中存在典型的Sézary细胞。其中一名患者的血液单核细胞培养物产生了HTLV-I样颗粒。虽然这两个病人都缺乏HTLV抗体，但他们的血液和皮肤标本证明含有taxandpolHTLV-I前病毒序列，如聚合酶链反应和Southern印迹分析所示。HIV和HTLV双重感染应考虑在诊断工作的患者的风险，即使在没有可证明的抗体。双重感染可能导致仅携带其中一种逆转录病毒的患者无法预期的临床表现和疾病进展。
Two homosexual HIV-infected patients with lymphocyte counts of <50 presented with intense pruritis, hyperpigmentation, and skin lesions clinically suggestive of the cutaneous T cell lymphoma, mycosis fungoides. On light microscopy, the skin biopsies were difficult to interpret because of the sparseness of the lymphocytic infiltrates. However, electron microscopy revealed typical Sézary cells in the peripheral blood and skin. Cultures of blood mononuclear cells of one of the patients generated HTLV-I-like particles. Although both patients lacked antibodies to HTLV, their blood and skin specimens proved to harbortaxandpolHTLV-I proviral sequences as shown by the polymerase chain reaction and Southern blot analysis. Dual infection with HIV and HTLV should be considered in the diagnostic work-up of patients at risk, even in the absence of demonstrable antibodies. Dual infections could result in clinical manifestations and evolution of disease not anticipated in patients who harbor only one of these retroviruses.