Interaction of the fluoroquinolone antibiotic, ofloxacin, with titanium oxide nanoparticles in water: adsorption and breakdown.
Interaction of the fluoroquinolone antibiotic, ofloxacin, with titanium oxide nanoparticles in water: adsorption and breakdown.
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DOI：
10.1016/j.scitotenv.2012.09.067
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发表时间：
2012-12
期刊：
影响因子：
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通讯作者：
E. V. Van Wieren;M. D. Seymour;J. Peterson
中科院分区：
文献类型：
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作者：
E. V. Van Wieren;M. D. Seymour;J. Peterson
氟喹诺酮类抗生素在天然水、土壤-水系统和废水中的迁移和命运部分受其表面与纳米（10 - 9m）金属氧化物颗粒的相互作用控制。实验将氧氟沙星（OFL）（一种常见的氟喹诺酮类人用和兽用抗生素）溶液与25nm-TiO2（锐钛矿酶）纳米颗粒在不同pH条件下混合。在初始OFL浓度为~3 ~ 690μM的药物纳米颗粒溶液中，观察到OFL的吸附和降解。虽然整体的等温线行为是对数的，但溶液中OFL的去除可以用线性去除系数（Kr）来近似。pH =4时Kr=42±8Lkg - 1, pH = 6时Kr=1288±217Lkg - 1, pH = 9时Kr=26±7Lkg - 1。在pH值为4的条件下对底物进行冲洗，tio2纳米颗粒从溶液中去除的原始OFL的大约11%被解吸。在pH为6的条件下，通过冲洗底物回收的OFL不到1%；在pH为9时，在初始混合实验中被纳米颗粒去除的OFL约有39%在冲洗过程中被解吸。在去除固体纳米颗粒后，对OFL溶液进行质谱分析，得到的离子表明，由于OFL在tio2表面的降解，存在去甲基化和去羧化的氟喹诺酮类物质。
The mobility and fate of fluoroquinolone antibiotics in natural waters, soil–water systems and wastewater are controlled in part by surface interactions with nanometer (10−9m) metal oxide particles. Experiments were performed by mixing solutions of ofloxacin (OFL), a common, fluoroquinolone-class human and veterinary antibiotic, with 25nm-TiO2(anatase) nanoparticles at different pH conditions. Both sorption and degradation of OFL were observed in the drug-nanoparticle solutions with initial OFL concentrations of ~3 to 690μM. Though overall isotherm behavior is logarithmic, OFL removal from the solution can be approximated by linear removal coefficients (Kr). At pH 4, Kr=42±8Lkg−1, at pH 6 Kr=1288±217Lkg−1, and at pH 9 Kr=26±7Lkg−1. Rinsing of substrates at pH 4 resulted in desorption of approximately 11% of the original OFL removed from the solution by TiO2nanoparticles. Less than 1% of the removed OFL at pH 6 was recovered by rinsing the substrate; and, at pH 9 about 39% of the OFL removed by nanoparticles during the initial mixing experiment was desorbed during rinsing. Mass spectral analysis of OFL solutions after the removal of the solid nanoparticles yielded ions that indicate the presence of de-methylated and de-carboxylated fluoroquinolone species, resulting from the degradation of OFL at the TiO2surface.