Age-related memory impairments are caused by alterations in glial activity at old ages.
Age-related memory impairments are caused by alterations in glial activity at old ages.
复制标题
与年龄相关的记忆障碍是由老年时神经胶质活动的改变引起的。
DOI：
10.1007/978-981-16-7977-3_16
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Minoru Saitoe.
中科院分区：
文献类型：
--
作者：
Motomi Matsuno;Minoru Saitoe.
随着年龄的增长，人们的记忆力会下降，这种现象被称为年龄相关记忆障碍（AMI）。急性心肌梗死是一个日益严重的社会问题，它严重降低了老年人的生活质量。AMI已在除人类以外的各种动物中进行了研究，包括小鼠、大鼠和果蝇。本文就果蝇AMI的研究进展作一综述。特别是，AMI在果蝇consists的年龄依赖性神经胶质细胞信号的改变。这阻止了胶质细胞在老年时为神经元信号提供必要的支持。神经胶质细胞信号的改变也与哺乳动物的AMI有关，这表明了改善老年人记忆力的可能方法。
As people grow older, their memory decreases, a phenomenon known as age-related memory impairment (AMI). AMI is increasing as a social problem, and it severely reduces the quality of life of elderly people. AMI has been studied in various animals other than humans, including mice, rats, andDrosophila. Here we review studies of AMI inDrosophila. In particular, AMI inDrosophilaconsists of an age-dependent alteration in neuron-glial signaling. This prevents glia from providing the necessary support for neuronal signaling at old ages. Alterations in neuron-glial signaling are also associated with AMI in mammals, suggesting possible methods of improving memory in the elderly.