Self-Referencing Optofluidic Ring Resonator Sensor for Highly Sensitive Biomolecular Detection
Self-Referencing Optofluidic Ring Resonator Sensor for Highly Sensitive Biomolecular Detection
复制标题
用于高灵敏度生物分子检测的自参考光流控环形谐振器传感器
DOI：
10.1021/ac402174x
复制
发表时间：
2013-10-01
影响因子：
7.4
通讯作者：
Xu, Lei
中科院分区：
文献类型：
--
作者：
Li, Ming;Wu, Xiang;Xu, Lei
无标记光学环形谐振腔传感器的噪声抑制技术是提高其在极小检测浓度下的生化分析检测实用传感能力的关键。我们已经开发了一种自参考光流体环形谐振器（SR-OFRR），以大大提高其作为无标记光学生物传感器的传感能力。通过监测耦合环谐振器系统上产生的模式分裂分离，共模噪声被抑制了2个数量级，而无需任何外部噪声抑制技术。在这项工作中，我们首先进行了理论分析，阐明传感原理，然后应用SR-OFRR生物传感器实验检测牛血清白蛋白的浓度检测限的顺序为1 pg/mL（类似于15 fM）。
The noise-suppression techniques of label-free optical ring resonator sensors are crucial to improve their practical sensing capabilities for biochemical analysis and detection in extremely small detection concentration. We have developed a self-referencing optofluidic ring resonator (SR-OFRR) to vastly improve its sensing capability as a label-free optical biosensor. By monitoring the mode-splitting separation generated on a coupled ring resonator system, the common-mode noise is suppressed by 2 orders of magnitude without any external noise-suppression techniques. In this work, we first carried out theoretical analysis to elucidate the sensing principle and then applied the SR-OFRR biosensor to experimentally detect bovine serum albumin with a concentration detection limit on the order of 1 pg/mL (similar to 15 fM).