Cognitive Performance before and during Hemodialysis: A Randomized Cross-Over Trial
Cognitive Performance before and during Hemodialysis: A Randomized Cross-Over Trial
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DOI：
10.1159/000356393
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发表时间：
2013-01-01
影响因子：
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通讯作者：
Sarnak, Mark J.
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文献类型：
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作者：
Drew, David A.;Tighiouart, Hocine;Sarnak, Mark J.
背景和目的：血液透析（HD）患者在透析过程中接受教育和咨询。很少有研究评估透析是否会改变认知能力。方法：采用随机交叉设计，40例患者被分配到两个序列之一：透析前1小时检测，1个月后透析第1小时检测（n = 21）；透析第1小时检测，1个月后透析前1小时检测（n = 19）。在每个测试期进行认知测试。混合回归模型评估透析效果（透析前与透析期间测试表现的差异），同时调整潜在学习（第一次和第二次测试之间的差异）。结果：在考虑测试时间的模型中，所有进行的认知测试在HD前1小时与第1小时之间的测试表现没有差异（p > 0.05）。在单词表学习和数字符号替代测试中，发现了第一和第二次测试之间的学习效应。结论：我们没有发现认知表现的差异取决于测试的时间，这表明在透析的第一个小时进行的认知测试是对认知表现的有效评估。(C) 2013 S. Karger AG，巴塞尔
Background and Aims: Hemodialysis (HD) patients are educated and counseled during the HD procedure. There are few studies assessing whether cognitive performance varies with dialysis. Methods: Using a randomized cross-over design, 40 patients were assigned to one of two sequences: testing 1 h before dialysis followed 1 month later by testing during the first hour of dialysis (n = 21) versus testing during the first hour of dialysis followed 1 month later by 1 h before dialysis (n = 19). Cognitive tests were administered at each testing period. Mixed regression models evaluated for a dialysis effect (difference between test performance before vs. during dialysis) while adjusting for potential learning (difference between first and second tests). Results: In models accounting for period of testing, there was no difference in test performance between 1 h before versus during the first hour of HD for all administered cognitive tests (p > 0.05). A learning effect was detected between first and second test administration in two tests, specifically, the Word List Learning and the Digit Symbol Substitution Test. Conclusions: We found no difference in cognitive performance depending on the time of testing, suggesting that cognitive tests performed during the first hour of dialysis are a valid assessment of cognitive performance. (C) 2013 S. Karger AG, Basel