Experimental radioimmunotherapy with186Re-MAG3-A7 anti-colorectal cancer monoclonal antibody: Comparison with131I-counterpart
Experimental radioimmunotherapy with186Re-MAG3-A7 anti-colorectal cancer monoclonal antibody: Comparison with131I-counterpart
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186Re-MAG3-A7抗结直肠癌单克隆抗体实验性放射免疫治疗：与131I对应物的比较
DOI：
10.1007/bf02987831
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发表时间：
2001
影响因子：
2.6
通讯作者：
N. Tonami
中科院分区：
文献类型：
--
作者：
S. Kinuya;K. Yokoyama;K. Kobayashi;S. Motoishi;K. Onoma;N. Watanabe;N. Shuke;H. Bunko;T. Michigishi;N. Tonami
用~（186）Re与巯基乙酰三甘氨酸（MAG_3）螯合的方法标记了鼠抗人大肠癌肿瘤相关糖蛋白A_7的IgG_1。其比活度为119 MBq/mg，这对于治疗目的来说是足够高的，并且其免疫反应性被很好地保留为氯胺-T法标记的131 I-A7。人结肠癌裸鼠移植瘤（直径9.14±0.44 mm）的生长被静脉注射4.48 MBq的186 Re-A7显著抑制。186 Re-A7治疗效果优于4.63MBq的131 I-A7。通过体重变化评估的治疗毒性与两种缀合物相似。这些结果可能是由于肿瘤大小以及186 Re比131 I更有利的物理性质造成的。
A murine IgG1 against aMr 45 kD tumor-associated glycoprotein in human colorectal cancer, A7, was radiolabeled with186Re by a chelating method with a mercaptoacetyltriglycine (MAG3). Its specific activity was 119 MBq/mg, which would be high enough for a therapeutic purpose, and its immunoreactivity was preserved well as was131I-A7 labeled by the chloramine-T method. Growth of human colon cancer xenografts, 9.14±0.44 mm in diameter, in nude mice was significantly suppressed by an intravenous dose of 4.48 MBq of186Re-A7. The therapeutic outcome with186Re-A7 was better than that with 4.63 MBq of131I-A7. Toxicity of treatments assessed by body weight change was similar with both conjugates. These results are likely caused by the tumor size and more favorable physical properties of186Re than those of131I.
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影响因子：
158.5
作者：
KAMINSKI, MS;ZASADNY, KR;WAHL, RL
通讯作者：
WAHL, RL
影响因子：
11.2
作者：
Gary L. Griffiths;David M. Goldenberg;F. F. Knapp-F.;Alvin P. Callahan;Chien‐Hsing Chang;Hans J. Hansen
通讯作者：
Gary L. Griffiths;David M. Goldenberg;F. F. Knapp-F.;Alvin P. Callahan;Chien‐Hsing Chang;Hans J. Hansen
影响因子：
158.5
作者：
PRESS, OW;EARY, JF;BERNSTEIN, ID
通讯作者：
BERNSTEIN, ID
使用 N2S4 螯合物在体外和体内使用荷瘤裸鼠评估 186Re 标记抗体。
DOI：
10.1016/0883-2897(92)90009-n
发表时间：
1992
期刊：
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
影响因子：
--
作者：
Najafi,A;Alauddin,MM;Sosa,A;Ma,GQ;Chen,DC;Epstein,AL;Siegel,ME
通讯作者：
Siegel,ME