Modification of the radiation sensitivity of human tumour cells by a bis-benzimidazole derivative.
Modification of the radiation sensitivity of human tumour cells by a bis-benzimidazole derivative.
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双苯并咪唑衍生物改变人类肿瘤细胞的辐射敏感性。
DOI：
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
C. Anderson
中科院分区：
文献类型：
--
作者：
P. Smith;C. Anderson
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A comparison was made of the ability of either X-radiation or a DNA-specific ligand (the vital bis-benzimidazole dye; Hoechst 33342) to induce: cell killing, inhibition of de novo DNA synthesis, DNA strand breakage and the delay of cell division in human colon adenocarcinoma cells in vitro. Unlike radiation-induced cell killing, ligand-induced cytotoxicity appeared to be positively correlated with the extent of inhibition of de novo DNA synthesis--a feature consistent with the persistent binding of ligand molecules to nuclear DNA. Ligand-induced DNA strand-breaks disappeared slowly although ligand-treated cells retained apparently normal capacities to repair discrete radiogenic DNA strand-breaks. Pre-treatment of cells with Hoechst 33342 resulted in a dose-modifying enhancement of radiation resistance not associated with altered dosimetry for strand-break induction. However, radioresistance was accompanied by the protracted retention of cells in the G2 phase of the cell cycle. We suggest that the results provide direct evidence that the retention of cells in G2 phase is a sparing phenomenon and is triggered by the responses of chromatin domains to the presence of DNA damage. Our results have implications for the use of DNA-interactive agents in combined modalities for tumour therapy, and indicate a possible basis for the sparing of some tumour cells in dividing populations.
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伽马射线诱导的共济失调毛细血管扩张成纤维细胞 DNA 合成抑制是切除修复能力的函数。
DOI：
10.1016/0006-291x(80)91461-8
发表时间：
1980
影响因子：
3.1
作者：
Smith,PJ;Paterson,MC
通讯作者：
Paterson,MC
溴化乙锭诱导的 DNA 超螺旋变化对两种抗肿瘤抗生素博莱霉素和腐草霉素 DNA 降解活性的影响。
影响因子：
11.2
作者：
Huang,CH;Mirabelli,CK;Mong,S;Crooke,ST
通讯作者：
Crooke,ST
转录活性染色质中的 DNA 对电离辐射过敏。
DOI：
10.1016/0167-4781(82)90166-x
发表时间：
1982
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Chiu,SM;Oleinick,NL;Friedman,LR;Stambrook,PJ
通讯作者：
Stambrook,PJ
DOI：
10.1016/0005-2787(81)90145-3
发表时间：
1981-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
ROSS, WE;BRADLEY, MO
通讯作者：
BRADLEY, MO
溴化乙锭会改变抗肿瘤药物顺式二氨二氯铂 (II) 的核酸酶敏感 DNA 结合位点。
DOI：
10.1073/pnas.79.11.3489
发表时间：
1982
影响因子：
11.1
作者：
Tullius,TD;Lippard,SJ
通讯作者：
Lippard,SJ