Association between novel GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis
Association between novel GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis
复制标题
DOI：
10.1067/mai.2003.1699
复制
发表时间：
2003-09-01
影响因子：
14.2
通讯作者：
Arkwright, PD
中科院分区：
文献类型：
--
作者：
Rafatpanah, H;Bennett, E;Arkwright, PD
背景：遗传因素在决定个体特应性皮炎的易感性方面是重要的。目的：由于树突状细胞启动免疫反应，因此对个体对潜在过敏原的启动至关重要，我们假设控制这些细胞活性的遗传因素决定了个体对特应性皮炎的倾向。方法：我们研究了已知的IL-1 β和TNF-α基因的功能多态性，并描述了113名特应性皮炎儿童和114名对照儿童中GM-CSF基因的新多态性。已知所有3种因子都是皮肤朗格汉斯（树突）细胞功能的重要调节剂。结果如下：纯合子GM-CSF-677 *C/C基因型的遗传与该队列儿童中完全没有严重特应性皮炎相关（P <0.001）。结论：GM-CSF基因型是预测个体易患特应性皮炎的重要遗传标记。
Background: Genetic factors are known to be important in determining an individual's predisposition to atopic dermatitis. The specific genes that are clinically important in this process are still largely unknown.Objective: Because dendritic cells initiate immune responses and thus are critical to the priming of an individual to potential allergens, we hypothesized that genetic factors controlling the activity of these cells determine an individual's propensity to atopic dermatitis.Methods: We studied known functional polymorphisms of the IL-1beta and TNF-alpha genes and describe novel polymorphisms of the GM-CSF gene in 113 children with atopic dermatitis and 114 controls. All 3 factors are known to be important modulators of the function of skin Langerhans' (dendritic) cells. Results: The inheritance of a homozygous GM-CSF -677*C/C genotype was associated with complete absence of severe atopic dermatitis within this cohort of children (P < .001). Furthermore, the odds ratio of having atopic dermatitis in children who were not of this genotype was 7.5 (2.2-25).Conclusion: The GM-CSF genotype is an important genetic marker predicting an individual's predisposition to atopic dermatitis.