STATE DEPENDENT ACTIVITY IN MONKEY VISUAL-CORTEX .2. RETINAL AND EXTRARETINAL FACTORS IN V4
STATE DEPENDENT ACTIVITY IN MONKEY VISUAL-CORTEX .2. RETINAL AND EXTRARETINAL FACTORS IN V4
复制标题
DOI：
10.1007/bf00247570
复制
发表时间：
1988-01-01
影响因子：
2
通讯作者：
SCHILLER, PH
中科院分区：
文献类型：
--
作者：
HAENNY, PE;MAUNSELL, JHR;SCHILLER, PH
当恒河猴对样本任务进行定向匹配时，记录了它们视觉皮层中孤立神经元的反应。在每次试验中，首先用随机选择的方向提示动物，然后呈现一系列方向随机选择的光栅。要求动物在看到与提示方向匹配的格栅时释放开关。在一些记录中，动物通过感觉它看不到的凹槽板的方向来获得触觉提示。在其他实验中，提示方向被视觉呈现在动物面前的屏幕上，然后在呈现光栅序列之前被移除。通过这项任务，可以确定神经元对特定方向的反应是否受到动物正在寻找的方向的影响。当动物被提示寻找不同的方向时，在V4中检查的超过一半的神经元（110/192）对视觉刺激有不同的反应。对于某些神经元来说，当动物被提示寻找特定方向时，对所有刺激的反应都很强，但当在动物被提示寻找另一个方向的试验中出现相同刺激时，反应很弱。这种类型的敏感性在动物被给予触觉提示时记录的神经元中被发现，并且在使用视觉提示时测试的其他神经元中也被发现，这表明活动不是直接的感觉来源。为了支持这一点，当动物在不执行方向匹配任务的情况下感觉到凹槽板时，V4中的神经元没有受到强烈影响。使用方向匹配任务发现的行为效应的患病率表明，视网膜外信号代表了行为猴子V4活动的突出组成部分。
Responses were recorded from isolated neurons in the visual cortex of rhesus monkeys while they performed an orientation match to sample tasks. In each trial the animal was first cued with randomly selected orientation, and then presented with a sequence of gratings whose orientations were randomly selected. The animal was required to release a switch when it saw a grating that matched the cued orientation. For some recordings the animal was given a tactile cue by having it feel the orientation of a grooved plate that it could not see. In other experiments the cue orientation was presented visually on the screen in front of the animal and then removed before the sequence of gratings was presented. Using this task it was possible to determine if a neuron''s response to a particular orientation was affected by whether or not it was the orientation for which the animal was looking. Over half the neurons examined in V4 (110/192) responded differently to the visual stimuli when the animal was cued to look for different orientations. For some neurons responses to all stimuli were strong when the animal was cued to look for a particular orientation, but weak when the same stimuli were presented in trials where the animal had been cued to look for another orientation. This type of sensitivity was found in neurons recorded while the animal was given a tactile cue, and also in other neurons tested when a visual cue was used, suggesting that the activity was not of direct sensory origin. In support of this, neurons in V4 were not strongly affected when the animal felt the grooved plate while not performing the orientation matching task. The prevalence of behavioral effects that was found using the orientation matching task suggests that extraretinal signals represent a prominent component of the activity in V4 of the behaving monkey.