Alcohol consumption and the prevalence of the metabolic syndrome in the US - A cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey
Alcohol consumption and the prevalence of the metabolic syndrome in the US - A cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey
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DOI：
10.2337/diacare.27.12.2954
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发表时间：
2004-12-01
期刊：
影响因子：
16.2
通讯作者：
Ellison, RC
中科院分区：
文献类型：
--
作者：
Freiberg, MS;Cabral, HJ;Ellison, RC
目的 - 本研究旨在探讨美国人群中饮酒与代谢综合征及其组成成分患病率之间的关系。
研究设计与方法 - 我们对第三次全国健康和营养检查调查中8125名参与者的数据进行了横断面分析，这些参与者依据美国国家胆固醇教育计划标准、空腹胰岛素水平以及饮酒情况对代谢综合征的各个组成成分进行了评估。当前饮酒定义为每月饮酒量大于或等于1杯。
结果 - 在对年龄、性别、种族/民族、教育程度、收入、吸烟情况、体力活动和饮食进行调整后，与当前不饮酒者相比，每月饮酒1 - 19杯以及大于或等于20杯的受试者患代谢综合征的比值比（OR）分别为0.65和0.34（所有P < 0.05）。这些发现对于饮用啤酒和葡萄酒的人尤为显著。每月饮酒大于或等于20杯与代谢综合征患病率之间的关联在不同种族中是一致的，但在白人男性和女性中最为显著（比值比分别为0.35和0.22；P < 0.05）。饮酒与代谢综合征的以下三个组成成分的患病率呈显著负相关：低血清高密度脂蛋白胆固醇、高血清甘油三酯、高腰臀比以及高胰岛素血症（所有P < 0.05）。
结论 - 轻度至中度饮酒与代谢综合征患病率较低相关，对血脂、腰臀比和空腹胰岛素有有利影响。这种关联在白人和饮用啤酒及葡萄酒的人群中最为强烈。
OBJECTIVE - The aim of this study was to examine the relations of alcohol consumption to the prevalence of the metabolic syndrome and its components in the U.S. population.RESEARCH DESIGN AND METHODS - We performed a cross-sectional analysis on data from 8,125 participants from the Third National Health and Nutrition Examination Survey who were evaluated for each component of the metabolic syndrome, using the National Cholesterol Education Program criteria, fasting insulin, and alcohol consumption. Current alcohol consumption was defined as greater than or equal to 1 alcoholic drink per month.RESULTS - After adjustment for age, sex, race/ethnicity, education, income, tobacco use, physical activity, and diet, subjects who consumed 1-19 and greater than or equal to20 drinks of alcohol per month had odds ratios (ORs) for the prevalence of the metabolic syndrome of 0.65 and 0.34, respectively (P < 0.05 for all), compared with current nondrinkers. These findings were particularly noteworthy for beer and wine drinkers. The association of greater than or equal to20 alcoholic drinks per month with the prevalence of the metabolic syndrome was consistent across ethnicities but was most striking in white men and women (ORs 0.35 and 0.22, respectively; P < 0.05). Alcohol consumption was significantly and inversely associated with the prevalence of the following three components of the metabolic syndrome: low serum HDL cholesterol, elevated serum triglycerides, high waist circumference, as well as hyperinsulinemia (P < 0.05 for all).CONCLUSIONS - Mild to moderate alcohol consumption is associated with a lower prevalence of the metabolic syndrome, with a favorable influence on lipids, waist circumference, and fasting insulin. This association was strongest among whites and among beer and wine drinkers.