An integrated model of Plasmodium falciparum dynamics
An integrated model of Plasmodium falciparum dynamics
复制标题
DOI：
10.1016/j.jtbi.2004.08.021
复制
发表时间：
2005-02-07
影响因子：
2
通讯作者：
Bossert, WH
中科院分区：
文献类型：
--
作者：
McKenzie, FE;Bossert, WH
疟疾的宿主内和宿主间动态以无数方式联系在一起，但最明显的是配子体，即可从人传播到蚊子的寄生虫血液形式。配子体动力学取决于那些非传染性的血液形式，刺激免疫反应，阻碍传播以及宿主内寄生虫密度。这些动态可以反过来影响抗原多样性和遗传上不同的寄生虫之间的重组。在这里，我们嵌入了一个微分方程模型的寄生虫免疫系统的相互作用，在每个人的代表在一个离散事件模型的恶性疟原虫传播，并检查人口流动的影响，寄生虫抗原多样性，重组，配子体生产疟疾的动态。我们的研究结果表明，恶性疟原虫的本地持久性增加营业额在人类人口和抗原多样性的寄生虫，特别是在组合，并在寄生虫减数分裂重组所产生的抗原多样性的持久性的创始人和后代基因型有复杂的差异性影响。我们还发现，减少个体人类感染蚊子的持续时间，即使是普遍的，产生人口水平的影响，只有当接近绝对的，而且，在竞争中，持久性和流行性的寄生虫基因型配子体生产与数据一致超过那些配子体生产更高的基因型。这种新的综合方法提供了一个框架，调查所有个体宿主内的病原体动态和相互作用的宿主和媒介种群内的病原体动态之间的关系。(C)2004 Elsevier Ltd.保留所有权利。
The within-host and between-host dynamics of malaria are linked in myriad ways, but most obviously by gametocytes, the parasite blood forms transmissible from human to mosquito. Gametocyte dynamics depend on those of non-transmissible blood forms, which stimulate immune responses, impeding transmission as well as within-host parasite densities. These dynamics can, in turn, influence antigenic diversity and recombination between genetically distinct parasites. Here, we embed a differential-equation model of parasite-immune system interactions within each of the individual humans represented in a discrete-event model of Plasmodium falciparum transmission, and examine the effects of human population turnover, parasite antigenic diversity, recombination, and gametocyte production on the dynamics of malaria. Our results indicate that the local persistence of P. falciparum increases with turnover in the human population and antigenic diversity in the parasite, particularly in combination, and that antigenic diversity arising from meiotic recombination in the parasite has complex differential effects on the persistence of founder and progeny genotypes. We also find that reductions in the duration of individual human infectivity to mosquitoes, even if universal, produce population-level effects only if near-absolute, and that, in competition, the persistence and prevalence of parasite genotypes with gametocyte production concordant with data exceed those of genotypes with higher gametocyte production. This new, integrated approach provides a framework for investigating relation ships between pathogen dynamics within ail individual host and pathogen dynamics within interacting host and vector populations. (C) 2004 Elsevier Ltd. All rights reserved.