Dietary fat ingestion activates β-endorphin neurons in the hypothalamus
Dietary fat ingestion activates β-endorphin neurons in the hypothalamus
复制标题
DOI：
10.1016/j.febslet.2012.03.028
复制
发表时间：
2012-04-24
期刊：
影响因子：
3.5
通讯作者：
Fushiki, Tohru
中科院分区：
文献类型：
--
作者：
Matsumura, Shigenobu;Eguchi, Ai;Fushiki, Tohru
阿片系统调节食物的选择、消耗和强化过程，特别是对于美味的食物，如脂肪食物。β-内啡肽是下丘脑神经元产生的一种内源性阿片肽。在这项研究中，我们发现Intralipid(脂肪乳剂)摄入增加了β-内啡肽神经元中c-fos的表达。然而，灌胃Intralipid仅在给药后2 h轻微增加c-fos的表达。此外，切断舌咽神经，支配舌后味蕾，部分但显著地降低了Intralipid诱导的c-fos表达。这些结果表明，主要是来自脂肪的口感刺激可能激活了β-内啡肽神经元，从而促进了β-内啡肽的释放。(C)2012年欧洲生化学会联合会。爱思唯尔出版公司版权所有。
The opioid system regulates food choice, consumption, and reinforcement processes, especially for palatable meals such as fatty food. beta-Endorphin is known as an endogenous opioid peptide produced in neurons of the hypothalamus. In this study, we found that Intralipid (fat emulsion) ingestion increased c-fos expression in beta-endorphin neurons. However, intragastric infusion of Intralipid only slightly increased c-fos expression 2 h after infusion. Further, dissection of glossopharyngeal nerve, innervating posterior tongue taste buds, partially but significantly decreased the Intralipid-induced c-fos expression. These results indicate that mainly the orosensory stimulation from fat may activate beta-endorphin neurons, thereby promoting beta-endorphin release. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.