Cerebellar Heterotopia in Infancy
Cerebellar Heterotopia in Infancy
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婴儿期小脑异位
DOI：
10.1111/j.1469-8749.1968.tb02951.x
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发表时间：
1968
影响因子：
3.8
通讯作者：
H. Riggs
中科院分区：
文献类型：
--
作者：
L. Rorke;M. Fogelson;H. Riggs
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The cerebella of 200 infants were examined for dysplastic microscopic cell rests. Six of the infants had trisomy defects; 47 non‐trisomic babies showed only isolated somatic, non‐neural malformations and 147 cases displayed neither somatic nor cerebral malformations. Four types of cerebellar rests were identified. Most common were compact groups of mature neurons primarily localised in the white matter. These were found in about half the infants in each group. Less frequent were immature granular cell collections and poorly‐organised mixed cell rests or heterotaxias. These occurred significantly more often in babies with trisomy than in the other two groups. Very few heterotopias or well‐organised mixed cell rests were found, and there was no difference in the incidence between the three groups. Out of 6 infants with chromosomal trisomy, 5 (83 per cent) showed one or more of these dysplastic cerebellar cell rests. Since 82 per cent of the non‐trisomic cases had similar microscopic malformations, it appears unlikely that the chromosomal defect could be responsible for this curious anatomic abnormality.