Multi-spectral intravascular photoacoustic/ultrasound/optical coherence tomography tri-modality system with a fully-integrated 0.9-mm full field-of-view catheter for plaque vulnerability imaging
Multi-spectral intravascular photoacoustic/ultrasound/optical coherence tomography tri-modality system with a fully-integrated 0.9-mm full field-of-view catheter for plaque vulnerability imaging
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DOI：
10.1364/boe.420724
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发表时间：
2021-04-01
影响因子：
3.4
通讯作者：
SONG, L. I. A. N. G.
中科院分区：
文献类型：
--
作者：
LENG, J., I;ZHANG, J. I. N. K. E.;SONG, L. I. A. N. G.
心肌梗塞最常由所谓的易损斑块引起，通常表现为非阻塞性病变，具有富含脂质的坏死核心、薄帽纤维粥样斑块和大斑块。这些特征的识别和量化是评估斑块脆弱性的关键。然而，血管内超声、光学相干断层扫描和光声等单一模态血管内方法很难获得满足临床需求的所有综合信息。在本文中，我们首次开发了一种新型多光谱血管内三模态（MS-IVTM）成像系统，该系统可以进行360°旋转。利用0.9毫米微型导管连续旋转和回拉，实现形态特征和病理成分的同时采集。血管内三模态成像证明了我们的 MS-IVTM 系统能够提供血管壁的宏观和微观结构信息，以及通过多波长激发对脂质进行识别和定量。这项研究为临床医生和研究人员提供了一种新颖的成像工具，有助于准确诊断易损动脉粥样硬化斑块。它还具有临床转化的潜力，可以帮助在冠状动脉介入治疗期间更好地识别和评估高风险斑块。
Myocardial infarctions are most often caused by the so-called vulnerable plaques, usually featured as non-obstructive lesions with a lipid-rich necrotic core, thin-cap fibroatheroma, and large plaque size. The identification and quantification of these characteristics are the keys to evaluate plaque vulnerability. However, single modality intravascular methods, such as intravascular ultrasound, optical coherence tomography and photoacoustic, can hardly achieve all the comprehensive information to satisfy clinical needs. In this paper, for the first time, we developed a novel multi-spectral intravascular tri-modality (MS-IVTM) imaging system, which can perform 360? continuous rotation and pull-backing with a 0.9-mm miniature catheter and achieve simultaneous acquisition of both morphological characteristics and pathological compositions. Intravascular tri-modality imaging demonstrates the ability of our MS-IVTM system to provide macroscopic and microscopic structural information of the vessel wall, with identity and quantification of lipids with multi-wavelength excitation. This study offers clinicians and researchers a novel imaging tool to facilitate the accurate diagnosis of vulnerable atherosclerotic plaques. It also has the potential of clinical translations to help better identify and evaluate high-risk plaques during coronary interventions.