GDNF induces branching and increased cell proliferation in the ureter of the mouse
GDNF induces branching and increased cell proliferation in the ureter of the mouse
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DOI：
10.1006/dbio.1997.8745
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发表时间：
1997-12-01
影响因子：
2.7
通讯作者：
McMahon, AP
中科院分区：
文献类型：
--
作者：
Pepicelli, CV;Kispert, A;McMahon, AP
分泌的信号分子GDNF在后肾间充质中表达，最近被认为是后肾发育所必需的因素。我们研究了GDNF对小鼠肾脏移植的影响。我们发现GDNF促进了输尿管尖端的细胞增殖。输尿管尖端数目增多，邻近输尿管尖端扩张融合，部分输尿管尖端似乎向GDNF的源头生长。这些事件伴随着几个定位于TIPS的基因的转录上调，包括它自己的受体c-ret、转录因子Sox9和信号Wnt-11。这些结果支持一种模型，在该模型中，由间充质供应的GDNF通过输尿管尖端特异性因子的局部调节来调节后肾的生长和分支。(C)1997年学术出版社。
The secreted signaling molecule GDNF is expressed in the metanephric mesenchyme and has recently been implicated as a factor necessary for development of the metanephric kidney. We have examined the effects of GDNF on mouse kidney explants. We show that GDNF increases cell proliferation in ureter tips. There is an increase in the number of ureter tips and expansion and fusion of adjacent tips and some tips appear to grow toward the source of GDNF. These events are accompanied by transcriptional upregulation of several genes localized to the tips, including its own receptor, c-ret, the transcription factor Sox9, and the signal Wnt-11. These results support a model in which GDNF supplied by the mesenchyme regulates growth and branching in the metanephric kidney through the local regulation of ureter tip-specific factors. (C) 1997 Academic Press.