A2E, a byproduct of the visual cycle
A2E, a byproduct of the visual cycle
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DOI：
10.1016/s0042-6989(03)00475-9
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发表时间：
2003-12-01
期刊：
影响因子：
1.8
通讯作者：
Nakanishi, K
中科院分区：
文献类型：
--
作者：
Sparrow, JR;Fishkin, N;Nakanishi, K
随着年龄的增长和视网膜色素上皮（RPE）细胞中一些视网膜疾病中脂褐素的大量积累，是与光相关的维生素A循环的结果。RPE脂褐素的主要成分是双视网膜共轭物A2E及其光异构体。A2E的增加对细胞有影响，A2E的不良影响可归因于其两亲性结构和光反应性，这与萎缩性年龄相关性黄斑变性（AMD）与过度脂褐素积累之间的关联证据一致。(C) 2003 Elsevier Ltd.版权所有。
A substantial portion of the lipofuscin that accumulates with age and in some retinal disorders in retinal pigment epithelial (RPE) cells, forms as a consequence of light-related vitamin A recycling. Major constituents of RPE lipofuscin are the di-retinal conjugate A2E and its photoisomers. That the accretion of A2E has consequences for the cell, with the adverse effects of A2E being attributable to its amphiphilic structure and its photoreactivity, is consistent with evidence of an association between atrophic age-related macular degeneration (AMD) and excessive lipofuscin accumulation. (C) 2003 Elsevier Ltd. All rights reserved.