Mesenteric lymph nodes at the center of immune anatomy.
Mesenteric lymph nodes at the center of immune anatomy.
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DOI：
10.1084/jem.20060227
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发表时间：
2006-03-20
影响因子：
15.3
通讯作者：
Smith, Karen
中科院分区：
文献类型：
--
作者：
Macpherson, Andrew J;Smith, Karen
肠粘膜表面不断受到食物抗原和大量肠道微生物及其产物的侵袭，树突状细胞（DC）是这些微生物的采样点。最近的研究表明，肠系膜淋巴结（MLN）是诱导对食物蛋白质耐受的关键部位，并且它们还充当防火墙，以防止活肠道细菌穿透全身免疫系统。
The surface of the intestinal mucosa is constantly assaulted by food antigens and enormous numbers of commensal microbes and their products, which are sampled by dendritic cells (DCs). Recent work shows that the mesenteric lymph nodes (MLNs) are the key site for tolerance induction to food proteins and that they also act as a firewall to prevent live commensal intestinal bacteria from penetrating the systemic immune system.