Multiple functionalization of SBA-15 mesoporous silica in one-pot: fabricating an aluminum-containing plugged composite for sustained heparin release.
Multiple functionalization of SBA-15 mesoporous silica in one-pot: fabricating an aluminum-containing plugged composite for sustained heparin release.
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DOI：
10.1039/c3tb20425a
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发表时间：
2013-07
期刊：
影响因子：
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通讯作者：
M. Wan;W. Qian;W. Lin;Yu Zhou;J. Zhu
中科院分区：
文献类型：
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作者：
M. Wan;W. Qian;W. Lin;Yu Zhou;J. Zhu
为了制备一种广泛应用的抗凝血剂肝素的高效释放剂，采用一锅法合成了含铝封闭型介孔二氧化硅SBA-15。在起始混合物中加入合适的铝添加剂，可以在六角形通道内形成塞子，并将Al物种加入到介观结构中，这一点由粉末X射线衍射分析(XRD)、透射电子显微镜(TEM)、氮气吸附测量和27Al MAS核磁共振测试提供了证据。铝在SBA-15中的加入通过形成塞子降低了负电荷(Zeta-电位)并改变了通道的表面粗糙度，前者显著改善了对肝素的吸附，而后者抑制了肝素的释放。结果表明，这些修饰后的复合材料对肝素的吸附能力是亲本SBA-15的2-4倍，药物在几周内的释放量增加了60-130%；同时具有铝组分和塞状结构的样品可以维持肝素的释放6周，证明了多官能化SBA-15在肝素可控释放方面的效率，为设计新型药物释放剂提供了有价值的线索。
To fabricate an efficient releaser of heparin, which is an extensively used anticoagulant, aluminum containing plugged mesoporous silica SBA-15 is prepared using a one-pot synthesis process. A suitable aluminum additive in the starting mixture enables plugs to be formed inside hexagonal channels and Al species to be incorporated into the mesostructure, evidence for which is provided by powder X-ray diffraction analysis (XRD), transmission electron microscopy (TEM), N2 sorption measurements and 27Al MAS NMR tests. Incorporation of aluminum in SBA-15 reduces the negative charge (Zeta-potential) and tailors the surface roughness of the channel through forming plugs, and the former significantly improves heparin adsorption while the latter retards heparin release. As a result, these modified composites adsorb 2-4 times more heparin than parent SBA-15 and release 60-130% more of the drug over several weeks; the sample possessing both an Al-component and plug structure can sustain release of heparin for 6 weeks, demonstrating the increased efficiency of multiply functionalized SBA-15 in the controllable release of heparin and offering a valuable clue for design of novel drug releasers.