INFLUENCE OF MORBID-OBESITY AND NON-INSULIN-DEPENDENT DIABETES-MELLITUS ON HIGH-DENSITY-LIPOPROTEIN COMPOSITION AND SUBPOPULATION DISTRIBUTION
INFLUENCE OF MORBID-OBESITY AND NON-INSULIN-DEPENDENT DIABETES-MELLITUS ON HIGH-DENSITY-LIPOPROTEIN COMPOSITION AND SUBPOPULATION DISTRIBUTION
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DOI：
10.1016/0026-0495(92)90188-g
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发表时间：
1992-01-01
影响因子：
9.8
通讯作者：
CARPENTER, JW
中科院分区：
文献类型：
--
作者：
BARAKAT, HA;MCLENDON, VD;CARPENTER, JW
对18例糖耐量正常或非胰岛素依赖型糖尿病（NIDDM）的病态肥胖妇女和15例年龄匹配的瘦对照者的高密度脂蛋白（HDL）的化学组成、亚群分布和峰值水化密度进行了检测。在胃旁路手术减肥后的病态肥胖受试者中进行了类似的测量。在糖尿病组中，与瘦对照组相比，HDL蛋白质相对富集，胆固醇和胆固醇酯相对贫乏。在非糖尿病组中也观察到相同的趋势，尽管胆固醇酯差异不显著。在这两种情况下，电泳和密度梯度分析表明，血浆HDL含有更多的HDL 3和更少的HDL 2亚组分比瘦对照组。手术后，糖尿病组HDL的蛋白质百分比降低，胆固醇酯的百分比升高;非糖尿病组，蛋白质降低，磷脂增加。在糖尿病组中，电泳HDL亚群分布向更多HDL 2的转移伴随着这些变化。术后糖尿病组HDL的平均水合峰密度从HDL 3范围移至HDL 2范围;非糖尿病组的峰密度也降低，但仍保持在HDL 3范围内。在所有情况下，糖尿病患者之间的差异更为明显。胃旁路手术后高密度脂蛋白性质的这些变化可能会有利地影响通常与糖尿病相关的冠心病的风险。
The chemical composition, subpopulation distribution and peak hydrated density of high-density lipoprotein (HDL) were examined in 18 morbidly obese women with either normal glucose tolerance or with non-insulin-dependent diabetes mellitus (NIDDM), and in 15 age-matched lean control subjects. Similar measurements were made in the morbidly obese subjects after gastric bypass surgery for weight loss. In the diabetic' group, HDL was relatively protein-enriched and cholesterol- and cholesterol ester-poor compared with the lean controls. The same trend was seen in the nondiabetic group, although the cholesterol ester difference was not significant. In both cases, both electrophoretic and density gradient analysis showed that plasma HDL contained more of the HDL3and less of the HDL2subfractions than that for the lean controls. Following surgery in the diabetic group, the protein percentage of HDL decreased, and that of cholesterol ester increased; for the nondiabetic group, the protein decreased and phospholipid increased. In the diabetic group, a shift of the electrophoretic HDL subpopulation distribution toward more HDL2accompanied these changes. Average hydrated peak density of HDL shifted from the HDL3to the HDL2range for the diabetic group following surgery; for the nondiabetic group the peak density also decreased but still remained within the HDL3range. In all cases, the differences seen were more pronounced among the diabetic patients. These changes in the properties of HDL after gastric bypass surgery may favorably influence the risk for coronary heart disease usually associated with diabetes.