NOMA IN CHILDREN WITH SEVERE COMBINED IMMUNODEFICIENCY
NOMA IN CHILDREN WITH SEVERE COMBINED IMMUNODEFICIENCY
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DOI：
10.1016/s0022-3476(86)80219-0
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发表时间：
1986-10-01
影响因子：
5.1
通讯作者：
ESSEX, M
中科院分区：
文献类型：
--
作者：
ROTBART, HA;LEVIN, MJ;ESSEX, M
三名患有严重联合免疫缺陷的美洲原住民儿童患上了坏死性牙龈口炎，这是一种以前在这个国家没有报道的疾病。临床结果与在猴子身上观察到的猴子艾滋病的相似之处促使我们评估我们的患者及其家人是否感染了人类逆转录病毒。在患者或其家属中未发现HTLV-I或HTLV-III/LAV蛋白抗体。标准的细菌和病毒培养同样未能识别出可疑的病原体。
Three Native American children with severe combined immunodeficiency developed noma, a necrotizing gingivostomatitis not previously reported in this country. The similarity between the clinical findings and those observed in monkeys with simian AIDS prompted us to evaluate our patients and their families for human retroviral infection. Antibodies to HTLV-I or HTLV-III/LAV proteins were not identified in patients nor in their family members. Standard bacterial and viral cultures similarly failed to identify a suspect pathogen.