Role of Hepatic Aryl Hydrocarbon Receptor in Non-Alcoholic Fatty Liver Disease.
Role of Hepatic Aryl Hydrocarbon Receptor in Non-Alcoholic Fatty Liver Disease.
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DOI：
10.3390/receptors2010001
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发表时间：
2023-03
期刊：
影响因子：
--
通讯作者：
Joshi AD
中科院分区：
文献类型：
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作者：
Patil NY;Friedman JE;Joshi AD
在非酒精性脂肪性肝病(NAFLD)的研究中，许多核受体包括法尼类X受体、肝X受体、过氧化物酶体增殖物激活受体、孕烷X受体、肝细胞核因子等已被广泛研究。芳香烃受体(AhR)在20世纪70年代首次被描述，几十年的研究揭示了其在毒性和病理生理过程中的作用，但AhR在NAFLD中的功能意义尚未完全破译。最近，多个研究小组利用大量模拟NAFLD病理的体外和体内模型来研究AhR在脂肪肝疾病中的功能意义。这篇综述对描述AhR在NAFLD中的有益和可能的有害作用的研究进行了全面的描述。讨论了NAFLD中认为AhR是一把“双刃剑”这一悖论的一种可能的调和。最后，了解AhR配体及其在NAFLD中的信号转导将有助于我们探索AhR作为潜在的药物靶点，在不久的将来设计针对NAFLD的创新疗法。
Numerous nuclear receptors including farnesoid X receptor, liver X receptor, peroxisome proliferator-activated receptors, pregnane X receptor, hepatic nuclear factors have been extensively studied within the context of non-alcoholic fatty liver disease (NAFLD). Following the first description of the Aryl hydrocarbon Receptor (AhR) in the 1970s and decades of research which unveiled its role in toxicity and pathophysiological processes, the functional significance of AhR in NAFLD has not been completely decoded. Recently, multiple research groups have utilized a plethora of in vitro and in vivo models that mimic NAFLD pathology to investigate the functional significance of AhR in fatty liver disease. This review provides a comprehensive account of studies describing both the beneficial and possible detrimental role of AhR in NAFLD. A plausible reconciliation for the paradox indicating AhR as a ‘double-edged sword’ in NAFLD is discussed. Finally, understanding AhR ligands and their signaling in NAFLD will facilitate us to probe AhR as a potential drug target to design innovative therapeutics against NAFLD in the near future.