Asymmetric total synthesis of (+)-phoslactomycin B.
Asymmetric total synthesis of (+)-phoslactomycin B.
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DOI：
10.1021/ol8004672
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发表时间：
2008-05
期刊：
影响因子：
5.2
通讯作者：
S. Shibahara;M. Fujino;Yasumasa Tashiro;Keisuke Takahashi;Jun Ishihara;S. Hatakeyama
中科院分区：
文献类型：
--
作者：
S. Shibahara;M. Fujino;Yasumasa Tashiro;Keisuke Takahashi;Jun Ishihara;S. Hatakeyama
通过不对称戊烯化、Suzuki-Miyaura偶联、关环复分解、不对称双羟基化和Stille偶联等高对映体和立体选择性的方法合成了（+）-磷霉素B。开发的合成方法，使我们能够合成其他三个异构体有关的C11-OH和Delta 12-双键。
(+)-Phoslactomycin B was synthesized by a highly enantio- and stereoselective approach involving asymmetric pentenylation, Suzuki-Miyaura coupling, ring-closing metathesis, asymmetric dihydroxylation, and Stille coupling. The synthetic method developed enables us to synthesize three other isomers concerning the C11-OH and Delta12-double bond.