Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population
Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population
复制标题
日本人群中低 Km 醛脱氢酶三种基因型的特征
DOI：
10.1007/bf00208273
复制
发表时间：
1994
期刊：
影响因子：
5.3
通讯作者：
J. Furuyama
中科院分区：
文献类型：
--
作者：
T. Takeshita;K. Morimoto;XiaoQuang Mao;T. Hashimoto;J. Furuyama
低KM乙醛脱氢酶(ALDH2)缺乏被认为是导致“东方潮红”等酒精敏感症状的主要因素。在这项研究中，使用一种新的、快速的非同位素聚合酶链式反应(PCR)方法，研究了524名日本工人ALDH2基因与酒精相关症状和饮酒行为的关系。在正常纯合子和其他缺陷类型之间，酒精相关表现的频率明显不同。此外，在ALDH2缺陷个体中，非典型纯合子明显比杂合子对酒精更敏感，从小剂量酒精引起的潮红或其他与饮酒相关的表现来看。饮酒频率由高到低依次为：典型纯合子>杂合子>非典型纯合子。同样，平均饮酒量也以相同的顺序减少，尽管在典型的纯合子组和杂合子组中存在相当大的差异。相比之下，男性酒精脱氢酶β亚单位(Adh2)基因的多态通常都不会影响这些表现和饮酒行为。这些发现进一步表明ALDH2基因对东方人的酒精敏感性有重要贡献。
A deficiency in low Km aldehyde dehydrogenase (ALDH2) is regarded as the main factor responsible for “Oriental flushing” and other symptoms due to alcohol sensitivity. In this study, the relationship of the ALDH2 genotype to alcohol-associated symptoms and drinking behavior was investigated in 524 Japanese workers, using a new, rapid, and nonisotopic polymerase chain reaction (PCR) method. Differences in the frequency of alcohol-associated manifestations between the normal homozygote and the other deficient types were apparent. In addition, among the ALDH2-deficient individuals, the atypical homozygote was obviously more hypersensitive to alcohol than the heterozygote, judging from the frequency of flushing or other drinking-associated manifestations with a small dose of alcohol. Drinking frequency also apparently decreased in the following order: typical homozygote, heterozygote, atypical homozygote. Similarly, mean amounts of alcohol consumption also decreased in the same order, although considerable variation existed within the typical homozygote and the heterozygote group. In contrast, neither the manifestations nor the drinking behavior were, in general, influenced by polymorphism of the alcohol dehydrogenase β-subunit (ADH2) gene in males. These findings further indicate the important contribution of the ALDH2 genotype to alcohol sensitivity in Orientals.
登录
查看更多内容
影响因子：
9.8
作者：
A. Shibuya;Akira Yoshida
通讯作者：
A. Shibuya;Akira Yoshida
直接检测人乙醛脱氢酶 2 (ALDH2) 位点上的常见和非典型等位基因。
影响因子：
9.8
作者：
Hsu,LC;Bendel,RE;Yoshida,A
通讯作者：
Yoshida,A
影响因子：
2.9
作者：
YIN, SJ;BOSRON, WF;LI, TK
通讯作者：
LI, TK
DOI：
10.1073/pnas.82.11.3771
发表时间：
1985-01-01
影响因子：
11.1
作者：
HSU, LC;TANI, K;YOSHIDA, A
通讯作者：
YOSHIDA, A
DOI：
10.1073/pnas.81.1.258
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
YOSHIDA, A;HUANG, IY;IKAWA, M
通讯作者：
IKAWA, M