Black/white differences in leukocyte subpopulations in men
Black/white differences in leukocyte subpopulations in men
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DOI：
10.1093/ije/26.4.757
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发表时间：
1997-08-01
影响因子：
7.7
通讯作者：
Byers, T
中科院分区：
文献类型：
--
作者：
Freedman, DS;Gates, L;Byers, T
背景。尽管黑人和白人之间的白细胞计数存在显着差异，并且可以预测缺血性心脏病 (IHD)，但白细胞亚群计数的种族差异较少受到关注。方法。我们检查了 3467 名曾在美国陆军服役的 31-45 岁白人和 493 名黑人白细胞亚群的黑人/白人差异。 1985-1986 年期间在一个中心地点进行了实验室测定。结果。黑人的平均白细胞总数比白人低 840 个细胞/μL（或 15%），主要是由于平均中性粒细胞计数低 960 个细胞/μL（或 25%）。尽管黑人的平均单核细胞计数（约 70 个细胞/μL）也比白人低 20%，但他们的平均淋巴细胞计数高 10%（约 200 个细胞/μL）。细胞/μl）。各种白细胞亚群的计数与吸烟、血红蛋白水平、血小板计数和其他几个特征相关，但中性粒细胞、淋巴细胞、单核细胞和其他亚群计数的黑白差异不能归因于任何检查的协变量。结论。尽管黑人的白细胞和中性粒细胞计数相对较低，但他们的淋巴细胞计数普遍高于白人。各种细胞类型计数的黑/白差异可能会影响种族特异性 IHD 发生率，未来的研究应尝试评估白细胞亚群在临床疾病发展中的重要性。
Background. Although counts of leukocytes differ substantially between blacks and whites, and are predictive of ischaemic heart disease (IHD), racial differences in counts of leukocyte subpopulations have received less attention.Methods. We examined black/white differences in leukocyte subpopulations among 3467 white and 493 black 31-45 year-old-men who had previously served in the US Army. Laboratory determinations were performed at a central location during 1985-1986.Results. Black men had an 840 cell/mu l (or 15%) lower mean total leukocyte count than did white men, largely due to a 960 cell/mu l (or 25%) lower mean neutrophil count, Although black men also had a 20% lower mean monocyte count (approximate to 70 cells/mu l) than did white men, their mean lymphocyte count was 10% higher (approximate to 200 cells/mu l). Counts of various leukocyte subpopulations were associated with cigarette smoking, haemoglobin levels, platelet counts, and several other characteristics, but black/white differences in counts of neutrophils, lymphocytes, monocytes and other subpopulations could not be attributed to any of the examined covariates.Conclusions. Despite the relatively low counts of leukocytes and neutrophils among black men, their lymphocyte counts are generally higher than those among white men. It is possible that black/white differences in counts of various cell types may influence race-specific rates of IHD, and future studies should attempt to assess the importance of leukocyte subpopulations in the development of clinical disease.