Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation
Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation
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DOI：
10.1111/j.1469-7793.2000.t01-1-00633.x
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发表时间：
2000-09-15
影响因子：
5.5
通讯作者：
Paulus, W
中科院分区：
文献类型：
--
作者：
Nitsche, MA;Paulus, W
1.在本文中，我们证明了在完整的人的可能性，一个非侵入性调制运动皮层兴奋性的应用程序通过头皮弱直流电。经颅磁刺激显示兴奋性变化高达40%，并在电流刺激结束后持续数分钟。阳极刺激可以选择性地实现兴奋，阴极刺激可以选择性地实现抑制.通过改变电流强度和持续时间，可以控制后效的强度和持续时间.这种效应可能是由膜极化的改变引起的。与强直后增强、短时程增强和类似于兴奋后中枢抑制的过程相关的功能改变是刺激结束后兴奋性变化的可能候选者。因此，使用弱电流的经颅电刺激可能是一种有前途的工具，以无创、无痛、可逆、选择性和局部的方式调节大脑兴奋性。
1. In this paper we demonstrate in the intact human the possibility of a non-invasive modulation of motor cortex excitability by the application of weak direct current through the scalp.2. Excitability changes of up to 40%, revealed by transcranial magnetic stimulation, were accomplished and lasted for several minutes after the end of current stimulation.3. Excitation could be achieved selectively by anodal stimulation, and inhibition by cathodal stimulation.4. By varying the current intensity and duration, the strength and duration of the after-effects could be controlled.5. The effects were probably induced by modification of membrane polarisation. Functional alterations related to post-tetanic potentiation, short-term potentiation and processes similar to postexcitatory central inhibition are the likely candidates for the excitability changes after the end of stimulation. Transcranial electrical stimulation using weak current may thus be a promising tool to modulate cerebral excitability in a non-invasive, painless, reversible, selective and focal way.