Recent progress in Bacillus subtilis two-component regulation.
Recent progress in Bacillus subtilis two-component regulation.
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DOI：
10.2741/ogura
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发表时间：
2002-08
期刊：
影响因子：
--
通讯作者：
M. Ogura;Teruo Tanaka
中科院分区：
文献类型：
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作者：
M. Ogura;Teruo Tanaka
双组分调控系统用于响应环境和生理变化来控制基因表达。它们广泛存在于各种生物体中，最常见于原核生物中。其中一种革兰氏阳性微生物枯草芽孢杆菌是一种经过充分研究的细菌，其完整的核苷酸序列已经确定。因此，现在可以用微阵列分析来研究整个基因组的转录。本文就B的研究进展作一综述。通过描述已知的系统和那些最近分配的功能，枯草双组分调节系统。还包括试图构建一个部分转录网络，涉及几个双组分系统。这里描述的研究是基于传统的遗传学和生物化学的数据，并从29个双组分系统的微阵列分析。
Two-component regulatory systems serve to control gene expression in response to environmental and physiological changes. They are widespread among a variety of organisms and most often found in prokaryotes. One of the gram-positive microorganisms Bacillus subtilis is a well-studied bacterium whose complete nucleotide sequence has been determined. Thus, it is now possible to study transcription of the whole genome with microarray analysis. In this review we summarize the recent progress in B. subtilis two-component regulatory systems by describing the known systems and those for which the function was recently assigned. Also included is an attempt to construct a partial transcriptional network involving several two-component systems. The studies described here are based on the data from traditional genetics and biochemistry, and from microarray analysis of 29 two-component systems.