Abnormal serotonin transporter availability in the brains of adults with conduct disorder
Abnormal serotonin transporter availability in the brains of adults with conduct disorder
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DOI：
10.1016/j.jfma.2016.07.012
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发表时间：
2017-06-01
影响因子：
3.2
通讯作者：
Yeh, Chin-Bin
中科院分区：
文献类型：
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作者：
Chang, Chieh;Gau, Susan Shur-Fen;Yeh, Chin-Bin
背景/目的：本研究的目的是确定品行障碍 (CD) 患者是否表现出血清素再摄取转运蛋白 (SERT) 可用性异常，以及他们的多动症状、冲动和生活质量是否与 SERT 可用性相关。方法：我们招募了 14 名未接受药物治疗的 CD 患者和 8 名年龄匹配的健康对照 (HC)。采用成人注意力缺陷/多动障碍（ADHD）自我报告量表（ASRS）、巴雷特冲动量表（BIS）和世界卫生组织生活质量简述版（WHOQOL-BREF）量表。安排使用 4-[F-18]-ADAM 的大脑正电子发射断层扫描 (PET) 进行 SERT 成像。结果：CD 患者纹状体和中脑的 SERT 可用性显着降低。生活质量和注意力不集中症状也与前额皮质 SERT 可用性显着相关。结论：研究表明 SERT 可用性的降低可能与 CD 相关，并且可能预测这些患者的生活质量差或注意力不集中症状。我们的研究结果的影响可能仅限于 CD 患者；未来有必要进行更大样本的研究来验证我们的初步结果。版权所有(C) 2016，台湾医学会。由爱思唯尔台湾有限公司出版。
Background/Purpose: The aims of the current study were to determine whether patients with conduct disorder (CD) showed an abnormal availability of serotonin reuptake transporter (SERT), and if their hyperkinetic symptoms, impulsivity, and quality of life were correlated with the availability of SERT.Methods: We recruited 14 drug-naive patients with CD and eight age-matched healthy controls (HCs). The adult attention-deficit/hyperactivity disorder (ADHD) self-report scale (ASRS), Barrett impulsivity scale (BIS), and the World Health Organization quality of life-brief version (WHOQOL-BREF) scale were administered. Positron emission tomography (PET) of the brain with 4-[F-18]-ADAM was arranged for SERT imaging.Results: SERT availability was significantly reduced in the striatum and midbrain of patients with CD. Quality of life and inattention symptoms were also significantly correlated with the availability of SERT in the prefrontal cortex.Conclusion: The study suggested that a reduction in the availability of SERT might be associated with CD and could potentially predict poor quality of life or symptoms of inattention for these patients. The implications of our results might be limited to individuals with CD; a future study with a larger sample to validate our preliminary results is warranted. Copyright (C) 2016, Formosan Medical Association. Published by Elsevier Taiwan LLC.