Psychiatric manifestations in systemic lupus erythematosus
Psychiatric manifestations in systemic lupus erythematosus
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DOI：
10.1016/j.autrev.2007.02.007
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发表时间：
2007-06-01
影响因子：
13.6
通讯作者：
Sikanich, Natasa
中科院分区：
文献类型：
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作者：
Stojanovich, Ljudmila;Zandman-Goddard, Gisele;Sikanich, Natasa
精神异常在系统性红斑狼疮（SLE）中很常见，患病率为17%至75%，反映了患者选择和评估的不同方法，临床医生的不同专业方向，以及缺乏公认的诊断活动性神经精神狼疮（NPSLE）的共识。ACR神经精神狼疮命名委员会标准中包括的精神病综合征包括认知功能障碍、急性意识模糊状态（谵妄）、焦虑症、情绪障碍和精神病。在系统性红斑狼疮患者中，精神现象的识别和鉴别诊断是至关重要的。可能的机制包括血管损伤和致病抗体。治疗策略基于小型病例研究。本文就精神狼疮的临床表现、发病机制及目前的治疗方法作一综述。(C)2007 Elsevier B.V.保留所有权利。
Psychiatric abnormalities are common in systemic lupus erythematosus (SLE) with a prevalence of 17% to 75%, reflecting different methods of patient selection and assessment, the different professional orientation of clinicians, and lack of an accepted consensus for diagnosing active neuropsychiatric lupus (NPSLE). The psychiatric syndromes included in the ACR Neuropsychiatric Lupus Nomenclature Committee criteria are cognitive dysfunction, acute confusional state (delirium), anxiety disorder, mood disorder, and psychosis. In SLE patients, identification of psychiatric phenomena and the generation of a differential diagnosis are crucial. Possible mechanisms include vascular injury and pathogenic antibodies. Treatment strategies are based on small case studies. The purpose of this review is to discuss clinical manifestations, Pathogenesis and the present therapeutic options in psychiatric lupus. (C) 2007 Elsevier B.V. All rights reserved.