SEROTONIN INVOLVEMENT IN THE SPONTANEOUS-ALTERNATION ABILITY - A BEHAVIORAL-STUDY IN TRYPTOPHAN-RESTRICTED RATS
SEROTONIN INVOLVEMENT IN THE SPONTANEOUS-ALTERNATION ABILITY - A BEHAVIORAL-STUDY IN TRYPTOPHAN-RESTRICTED RATS
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DOI：
10.1016/0304-3940(95)11519-3
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发表时间：
1995-05-05
影响因子：
2.5
通讯作者：
FERIAVELASCO, A
中科院分区：
文献类型：
--
作者：
GONZALEZBURGOS, I;OLVERACORTES, E;FERIAVELASCO, A
自发交替（SA）由海马中的间隔胆碱能末端控制。 5-羟色胺能末端终止于海马的胆碱能神经末梢，并且在从断奶到 60 天龄期间喂食缺乏色氨酸的饮食的大鼠中研究了它们在 SA 中的可能作用。测试使用T型迷宫。 40 天时，色氨酸缺陷大鼠的 SA 增加，但这种效应在 60 天时消失。 5-羟色胺在 SA 的心理神经控制中发挥调节作用，可能是通过海马胆碱能末梢的突触前抑制实现的。
Spontaneous alternation (SA) is controlled by septal cholinergic terminals in the hippocampus. Serotoninergic terminals end on cholinergic nerve endings in the hippocampus, and their possible role in SA was investigated in rats fed with a tryptophan-deficient diet, from weaning to 60 days of age. A T-maze was used for the test. At the age of 40 days, an increase in SA occurred in the tryptophan deficient rats, although this effect disappeared by 60 days of age. A modulatory role of serotonin in the psychoneural control of SA is suggested, and it may be through presynaptic inhibition of hippocampal cholinergic terminals.