A High PD-L1 Expression in Pulmonary Pleomorphic Carcinoma Correlates with Parietal-pleural Invasion and Might Predict a Poor Prognosis
A High PD-L1 Expression in Pulmonary Pleomorphic Carcinoma Correlates with Parietal-pleural Invasion and Might Predict a Poor Prognosis
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DOI：
10.2169/internalmedicine.1462-18
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发表时间：
2019-01-01
影响因子：
1.2
通讯作者：
Atagi, Shinji
中科院分区：
文献类型：
--
作者：
Naito, Maiko;Tamiya, Akihiro;Atagi, Shinji
目的多形性癌是一种少见的肺上皮性恶性肿瘤，预后较差。本研究旨在探讨程序性死亡配体1 （programmed death-ligand 1, PD-L1）在原发性肝癌中的表达及其与临床病理因素与预后的关系。方法收集我院2002 ~ 2016年收治的35例手术切除的PC患者的临床及病理资料。免疫组化（克隆22C3）检测PD-L1在肿瘤细胞中的表达。我们研究了PD-L1表达与患者临床病理因素及预后的关系。结果21例（60%）患者PD-L1高表达（>= 50%），胸膜壁浸润与PD-L1高表达显著相关（p= 0.012）。5年总生存率为68.2%，无复发生存率为43.2%。肿瘤大小>= 50 mm （p= 0.021）、淋巴结转移（p= 0.023）、PD-L1高表达（p= 0.047）与短无复发生存期相关。由于淋巴结转移是总生存期差的独立危险因素（p= 0.012）， PD-L1高表达患者的总生存期也往往比低表达患者差（p= 0.081）。结论PD-L1在前列腺癌中高表达。PD-L1表达与胸膜壁层浸润有关，可能预示预后不良。
Objective Pleomorphic carcinoma (PC) is a rare pulmonary epithelial malignant tumor with a poor prognosis. The objective of the present study was to investigate the programmed death-ligand 1 (PD-L1) expression in PC and its correlation between the clinicopathological factors and prognosis.Methods Clinical and pathological data of 35 patients with surgically resected PC encountered from 2002 to 2016 at our institution were collected. The PD-L1 expression on tumor cells was evaluated via immunohistochemistry (clone 22C3). We examined the correlation between the PD-L1 expression and patients' clinicopathological factors and their prognosis.Results A high PD-L1 expression (>= 50%) was seen in 21 (60%) patients, and parietal-pleural invasion was significantly correlated with a high PD-L1 expression (p= 0.012). The 5-year overall survival and relapse-free survival were 68.2% and 43.2%, respectively. Tumor size >= 50 mm (p= 0.021), lymph node metastasis (p= 0.023), and a high PD-L1 expression (p= 0.047) were correlated with a short relapse-free survival. Since lymph node metastasis was an independent risk factor of a poor overall survival (p= 0.012), patients with a high PD-L1 expression also tended to have a worse overall survival than those with low levels (p= 0.081).Conclusion A high PD-L1 expression is frequently seen in PC. The PD-L1 expression is associated with parietal-pleural invasion and might indicate a poor prognosis.