Quantitative magnetic resonance imaging of brain development in premature and mature newborns
Quantitative magnetic resonance imaging of brain development in premature and mature newborns
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DOI：
10.1002/ana.410430213
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发表时间：
1998-02-01
影响因子：
11.2
通讯作者：
Volpe, JJ
中科院分区：
文献类型：
--
作者：
Hüppi, PS;Warfield, S;Volpe, JJ
定义在活的早产儿的解剖学和时间特征的发展的关键脑结构是至关重要的洞察时间最脆弱的大脑结构。我们使用三维磁共振成像（3D MRI）和图像处理算法对78例早产儿和足月儿（孕龄29-41周）的脑总体积和脑灰质（GM）、无髓鞘白色物质（WM）、有髓鞘WM和脑脊液（CSF）的总体积进行定量。总脑组织体积显示以22 ml/周的速率线性增加。总GM显示相对颅内体积每周线性增加约1.4%或绝对体积增加15 ml。总GM的显著增加主要反映了皮质GM增加了四倍。无髓鞘WM被认为是最突出的脑组织类早产儿小于36周的孕后年龄。尽管早产儿在29周时存在最小的有髓鞘WM，但在35周和41周之间，有髓鞘WM的绝对体积突然增加了5倍。脑外和脑室内CSF很容易通过这种技术定量，发现变化很小。3D MRI和组织分割的应用，从29至41周的孕后年龄的人类婴儿大脑的研究提供了新的见解大脑皮层发育和髓鞘形成，并首次提供了定量评估早期人类大脑发育的体内手段。
Definition in the living premature infant of the anatomical and temporal characteristics of development of critical brain structures is crucial for insight into the time of greatest vulnerability of such brain structures. We used three-dimensional magnetic resonance imaging (3D MRI) and image-processing algorithms to quantitate total brain volume and total volumes of cerebral gray matter (GM), unmyelinated white matter (WM), myelinated WM, and cerebrospinal fluid (CSF) in 78 premature and mature newborns (postconceptional age, 29-41 weeks). Total brain tissue volume was shown to increase linearly at a rate of 22 ml/wk. Total GM showed a linear increase in relative intracranial volume of approximately 1.4% or 15 mi in absolute volume per week. The pronounced increase in total GM reflected primarily a fourfold increase in cortical GM. Unmyelinated WM was found to be the most prominent brain tissue class in the preterm infant younger than 36 weeks of postconceptional age. Although minimal myelinated WM was present in the preterm infant at 29 weeks, between 35 and 41 weeks an abrupt fivefold increase in absolute volume of myelinated WM was documented. Extracerebral and intraventricular CSF was readily quantitated by this technique and found to change minimally. The application of 3D MRI and tissue segmentation to the study of human infant brain from 29 to 41 weeks of postconceptional age has provided new insights into cerebral cortical development and myelination and has for the first time provided means of quantitative assessment in vivo of early human brain development.