Solvent-cast 3D printing of magnesium scaffolds
Solvent-cast 3D printing of magnesium scaffolds
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DOI：
10.1016/j.actbio.2020.08.002
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发表时间：
2020-09-15
影响因子：
9.7
通讯作者：
Zhou, J.
中科院分区：
文献类型：
--
作者：
Dong, J.;Li, Y.;Zhou, J.
生物可降解多孔镁（Mg）支架在临界尺寸骨缺损的再生中具有良好的应用前景。虽然增材制造（AM）的承诺，提供独特的机会，制造多孔镁支架，目前的尝试，应用AM的方法来制造镁支架遇到了一些关键的问题，如那些有关的安全操作和组成控制的困难。在本文中，我们提出了一个室温挤出为基础的AM方法的拓扑有序多孔镁支架的制造。它由三个步骤组成，即（i）制备具有所需流变性能的Mg粉末负载油墨，（ii）油墨的溶剂浇铸3D打印（SC-3DP）以形成具有0度/ 90度/ 0度层的支架，以及（iii）脱脂和烧结以去除油墨中的粘合剂，然后通过应用液相烧结策略获得结合的Mg粉末颗粒。进行具有54、58和62体积% Mg粉末负载的所制备油墨的流变学分析以揭示其粘弹性。热重分析（TGA）、傅里叶变换红外光谱（FTIR）、碳/硫分析和扫描电子显微镜（SEM）分析表明，脱脂和烧结一步完成，可制备出具有高逼真度和致密性的纯镁支架。所得到的具有高孔隙率的支架含有分级和互连的孔。本研究首次证明了SC-3DP技术为制备镁基多孔支架提供了前所未有的可能性，这些支架具有作为骨替代材料的潜力。尽管增材制造（AM）有望提供制造多孔镁支架的独特机会，但目前尝试将AM方法应用于制造镁支架仍然具有一些关键的限制。这项研究表明，溶剂浇铸3D打印技术为制造镁基多孔支架提供了前所未有的可能性。配方粘结剂系统的明智选择允许脱脂后的粘结剂残留量可以忽略不计，并且短时间液相烧结策略导致烧结纯镁支架的巨大成功。由此得到的具有分级和互连孔的支架具有作为骨替代材料的巨大潜力。(C)2020 Acta Materialia Inc.爱思唯尔有限公司出版
Biodegradable porous magnesium (Mg) scaffolds are promising for application in the regeneration of critical-sized bone defects. Although additive manufacturing (AM) carries the promise of offering unique opportunities to fabricate porous Mg scaffolds, current attempts to apply the AM approach to fabricating Mg scaffolds have encountered some crucial issues, such as those related to safety in operation and to the difficulties in composition control. In this paper, we present a room-temperature extrusion-based AM method for the fabrication of topologically ordered porous Mg scaffolds. It is composed of three steps, namely (i) preparing a Mg powder loaded ink with desired rheological properties, (ii) solvent-cast 3D printing (SC-3DP) of the ink to form scaffolds with 0 degrees/ 90 degrees/ 0 degrees layers, and (iii) debinding and sin tering to remove the binder in the ink and then get Mg powder particles bonded by applying a liquidphase sintering strategy. A rheological analysis of the prepared inks with 54, 58 and 62 vol% Mg powder loading was performed to reveal their viscoelastic properties. Thermal-gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), carbon/sulfur analysis and scanning electron microscopy (SEM) indicated the possibilities of debinding and sintering at one single step for fabricating pure Mg scaffolds with high fidelity and densification. The resulting scaffolds with high porosity contained hierarchical and interconnected pores. This study, for the first time, demonstrated that the SC-3DP technique presents unprecedented possibilities to fabricate Mg-based porous scaffolds that have the potential to be used as a bone-substituting material.Statement of SignificanceBiodegradable porous magnesium scaffolds are promising for application in the regeneration of critical-sized bone defects. Although additive manufacturing (AM) carries the promise of offering unique opportunities to fabricate porous magnesium scaffolds, current attempts to apply the AM approach to fabricating magnesium scaffolds still have some crucial limitations. This study demonstrated that the solvent-cast 3D printing technique presents unprecedented possibilities to fabricate Mg-based porous scaffolds. The judicious chosen of formulated binder system allowed for the negligible binder residue after debinding and the short-time liquid-phase sintering strategy led to a great success in sintering pure magnesium scaffolds. The resulting scaffolds with hierarchical and interconnected pores have great potential to be used as a bone-substituting material. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd.