Phototransduction in Drosophila
Phototransduction in Drosophila
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DOI：
10.1007/s11427-012-4272-4
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发表时间：
2012-02
期刊：
影响因子：
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通讯作者：
Yao Tian;Wen Hu;Huawei Tong;Junhai Han
中科院分区：
文献类型：
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作者：
Yao Tian;Wen Hu;Huawei Tong;Junhai Han
果蝇视觉信号转导是已知最快的G蛋白偶联信号级联，并已被用作理解其他G蛋白偶联信号级联的分子机制的模型。视觉转导机制中的许多组件已经被确定。基于这些基因的功能特征，果蝇光信号转导的模型已被概述，包括视紫红质激活，磷酸肌醇信号，和开放的TRP和TRPL通道。最近，突变体的表征，显示缓慢终止，揭示了生理意义和光响应的快速终止机制。
TheDrosophilavisual transduction is the fastest known G protein-coupled signaling cascade and has been served as a model for understanding the molecular mechanisms of other G protein-coupled signaling cascades. Numbers of components in visual transduction machinery have been identified. Based on the functional characterization of these genes, a model forDrosophilaphototransduction has been outlined, including rhodopsin activation, phosphoinoside signaling, and the opening of TRP and TRPL channels. Recently, the characterization of mutants, showing slow termination, revealed the physiological significance and the mechanism of rapid termination of light response.