Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco:: a prospective longitudinal cohort study
Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco:: a prospective longitudinal cohort study
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DOI：
10.1016/s0140-6736(08)60135-x
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发表时间：
2008-01-19
期刊：
影响因子：
168.9
通讯作者：
Kilian, Mogens
中科院分区：
文献类型：
--
作者：
Haubek, Dorte;Ennibi, Oum-Keltoum;Kilian, Mogens
背景 牙周炎是牙齿周围支撑结缔组织和牙槽骨的丧失，如果以侵袭性形式发生，可能会导致 20 岁之前牙齿脱落。尽管牙周炎的病因总体上仍难以捉摸，但革兰氏阴性杆菌伴放线杆菌的特殊克隆 (JP2) 被认为是生活在或源自北非和西非的青少年中牙周炎侵袭性形式的可能病原体，这些地区牙周炎非常普遍。我们对青少年进行了一项基于人群的纵向研究，以评估 JP2 克隆在侵袭性牙周炎引发中的作用。方法 摩洛哥拉巴特公立学校的总共 700 名青少年参加了这项研究。我们使用 PCR 检测菌斑样本（取自磨牙和切牙位点）中的 A actinomycetemcomitans，并区分 JP2 克隆和细菌的其他非 JP2 基因型。 18 人被发现患有牙周炎并被排除。 682 名牙周健康青少年（平均年龄 12.5 岁；SD 1. 0）根据基线时的伴放线菌携带者状态进行分类。 2 年后，428 名 (62. 8%) 个体返回进行重新检查，其中包括记录从牙骨质-牙釉质交界处到所有牙齿牙周袋底部测量的牙周附着损失。结果 单独携带 A actinomycetemcomitans 的 JP2 克隆的个体（相对风险 18. 0；95% CI 7.8-41.2，p
Background Periodontitis is a loss of supporting connective tissue and alveolar bone around teeth, and if it occurs in an aggressive form it can lead to tooth loss before the age of 20 years. Although the cause of periodontitis in general remains elusive, a particular clone (JP2) of the gram-negative rod Aggregatibacter (Actinobacillus) actinomycetemcomitans is considered a possible aetiological agent of the aggressive form in adolescents living in or originating from north and west Africa, where the disease is highly prevalent. We did a population-based longitudinal study of adolescents to assess the role of the JP2 clone in the initiation of aggressive periodontitis.Methods A total of 700 adolescents from public schools in Rabat, Morocco, were enrolled in the study. We used PCR to detect A actinomycetemcomitans in plaque samples (taken from molar and incisor sites) and to differentiate between the JP2 clone and other non-JP2 genotypes of the bacterium. 18 individuals were found to already have periodontitis and were excluded. The 682 periodontally healthy adolescents (mean age 12.5 years; SD 1 . 0) were classified according to their A actinomycetemcomitans carrier status at baseline. After 2 years, 428 (62. 8%) individuals returned for re-examination, which included recording of periodontal attachment loss measured from the cemento-enamel junction to the bottom of the periodontal pockets of all teeth present.Findings Individuals who carried the JP2 clone of A actinomycetemcomitans alone (relative risk 18 . 0; 95% CI 7.8-41.2, p