Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells.
Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells.
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DOI：
10.1002/emmm.200900015
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发表时间：
2009-05
影响因子：
11.1
通讯作者：
Petit, Christine
中科院分区：
文献类型：
--
作者：
Bahloul, Amel;Simmler, Marie-Christine;Michel, Vincent;Leibovici, Michel;Perfettini, Isabelle;Roux, Isabelle;Weil, Dominique;Nouaille, Sylvie;Zuo, Jian;Zadro, Cristina;Licastro, Danilo;Gasparini, Paolo;Avan, Paul;Hardelin, Jean-Pierre;Petit, Christine
Loud sound exposure is a significant cause of hearing loss worldwide. We asked whether a lack of vezatin, an ubiquitous adherens junction protein, could result in noise-induced hearing loss. Conditional mutant mice bearing non-functional vezatin alleles only in the sensory cells of the inner ear (hair cells) indeed exhibited irreversible hearing loss after only one minute exposure to a 105 dB broadband sound. In addition, mutant mice spontaneously underwent late onset progressive hearing loss and vestibular dysfunction related to substantial hair cell death. We establish that vezatin is an integral membrane protein with two adjacent transmembrane domains, and cytoplasmic N- and C-terminal regions. Late recruitment of vezatin at junctions between MDCKII cells indicates that the protein does not play a role in the formation of junctions, but rather participates in their stability. Moreover, we show that vezatin directly interacts with radixin in its actin-binding conformation. Accordingly, we provide evidence that vezatin associates with actin filaments at cell–cell junctions. Our results emphasize the overlooked role of the junctions between hair cells and their supporting cells in the auditory epithelium resilience to sound trauma.
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DOI：
10.1083/jcb.93.1.97
发表时间：
1982-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fujiki Y;Hubbard AL;Fowler S;Lazarow PB
通讯作者：
Lazarow PB
磷酸肌醇的结合和磷酸化在ezrin的激活机理中依次起作用。
影响因子：
7.8
作者：
Fievet, BT;Gautreau, A;Roy, C;Del Maestro, L;Mangeat, P;Louvard, D;Arpin, M
通讯作者：
Arpin, M
影响因子：
64.8
作者：
Cavey, Matthieu;Rauzi, Matteo;Lecuit, Thomas
通讯作者：
Lecuit, Thomas
影响因子：
2.9
作者：
JONES, DT;TAYLOR, WR;THORTON, JM
通讯作者：
THORTON, JM
影响因子：
5.3
作者：
Furness, David N.;Mahendrasingam, Shanthini;Hackney, Carole M.
通讯作者：
Hackney, Carole M.