The glideosome: a molecular machine powering motility and host-cell invasion by apicomplexa
The glideosome: a molecular machine powering motility and host-cell invasion by apicomplexa
复制标题
DOI：
10.1016/j.tcb.2004.08.002
复制
发表时间：
2004-10-01
影响因子：
19
通讯作者：
Soldati, D
中科院分区：
文献类型：
--
作者：
Keeley, A;Soldati, D
顶复门是专性细胞内原生动物寄生虫，其依靠滑行运动性跨越生物屏障迁移以及宿主细胞侵入和外出。这种不寻常的底物依赖性运动形式是由“滑动体”提供动力的，“滑动体”是一种由粘附蛋白组成的大分子复合物，其通过锚定在寄生虫内膜复合物中的肌动球蛋白系统的作用从顶部释放并易位到寄生虫的后极。最近的研究揭示了弓形虫肌球蛋白-A运动复合体的组成和生物发生的新见解，并确定了一组令人兴奋的小分子，可以干扰滑体功能的不同方面。
The apicomplexans are obligate intracellular protozoan parasites that rely on gliding motility for their migration across biological barriers and for host-cell invasion and egress. This unusual form of substrate-dependent motility is powered by the 'glideosome', a macromolecular complex consisting of adhesive proteins that are released apically and translocated to the posterior pole of the parasite by the action of an actomyosin system anchored in the inner membrane complex of the parasite. Recent studies have revealed new insights into the composition and biogenesis of Toxoplasma gondii myosin-A motor complex and have identified an exciting set of small molecules that can interfere with different aspects of glideosome function.