Understanding how biologic and social determinants affect disparities in preterm birth and outcomes of preterm infants in the NICU.

Understanding how biologic and social determinants affect disparities in preterm birth and outcomes of preterm infants in the NICU.
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了解生物和社会决定因素如何影响早产差异和新生儿重症监护病房早产儿的结局。

DOI:
10.1016/j.semperi.2021.151408
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发表时间:
2021-06
影响因子:
3.4
通讯作者:
Wong, Ronald J.
Wong, Ronald J.
中科院分区:
医学3区
文献类型:
--
作者:
Stevenson, David K.;Aghaeepour, Nima;Maric, Ivana;Angst, Martin S.;Darmstadt, Gary L.;Druzin, Maurice L.;Gaudilliere, Brice;Ling, Xuefeng B.;Moufarrej, Mira N.;Peterson, Laura S.;Quake, Stephen R.;Relman, David A.;Snyder, Michael P.;Sylvester, Karl G.;Shaw, Gary M.;Wong, Ronald J.

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为了了解自发性早产(sPTB)和/或其结局的差异,应考虑生物学和社会决定因素以及医疗实践(如新生儿重症监护室)。sPTB的差异在很大程度上是棘手的,在大多数情况下仍然模糊,尽管有无数的确定的风险因素和sPTB的原因。我们仍然不知道它们如何导致不同胎龄的不同结果,以及它们是否独立于NICU实践。在这里,我们描述了一个综合的方法来研究基因组和染色体组之间的相互作用,这可能会推动生物化学和生理学,并导致健康的差异。
To understand the disparities in spontaneous preterm birth (sPTB) and/or its outcomes, biologic and social determinants as well as healthcare practice (such as those in neonatal intensive care units) should be considered. Disparities in sPTB have been largely intractable and remain obscure in most cases, despite a myriad of identified risk factors for and causes of sPTB. We still do not know how they lead to the different outcomes at different gestational ages and if they are independent of NICU practices. Here we describe an integrated approach to study the interplay between the genome and exposome, which may drive biochemistry and physiology and lead to health disparities.
DOI: 10.1007/s00281-019-00772-1
发表时间: 2020-08
影响因子: 9
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