Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways.
Betanin Prevents Experimental Abdominal Aortic Aneurysm Progression by Modulating the TLR4/NF-κB and Nrf2/HO-1 Pathways.
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DOI：
10.1248/bpb.b21-00042
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发表时间：
2021
影响因子：
2
通讯作者：
Renfeng Qiu;Shuxiao Chen;F. Hua;Shuai Bian;Jianfeng Chen;Gang Li;Xuejun Wu
中科院分区：
文献类型：
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作者：
Renfeng Qiu;Shuxiao Chen;F. Hua;Shuai Bian;Jianfeng Chen;Gang Li;Xuejun Wu
甜菜苷是一种主要从甜菜根中分离出来的生物活性成分，对心血管疾病具有保护作用。然而，其对腹主动脉瘤（AAA）的影响尚未阐明。在本研究中，通过向C57BL/6小鼠输注猪胰腺弹性蛋白酶来构建AAA模型。然后给小鼠灌胃甜菜碱或盐水，每天一次，持续 14 天。我们的结果表明，甜菜苷治疗显着限制了 AAA 的增大，并减轻了外膜中炎症细胞的浸润。甜菜苷治疗后促炎细胞因子和基质金属蛋白酶（MMP）表达的增加也显着减轻。此外，甜菜碱抑制主动脉壁中Toll样受体4（TLR4）/核因子-κB（NF-κB）信号传导的激活，并通过刺激核因子-E2相关因子2（Nrf2）/血红素加氧酶-1（HO-1）途径下调组织活性氧和循环8-异前列腺素的水平。综上所述，这些数据表明甜菜苷可以减缓 AAA 的进展，并可用作 AAA 的治疗药物。
Betanin, a bioactive ingredient mostly isolated from beetroots, exhibits a protective effect against cardiovascular diseases. However, its effects on abdominal aortic aneurysm (AAA) have not been elucidated. In this study, an AAA model was constructed by infusion of porcine pancreatic elastase in C57BL/6 mice. Mice were then administered with betanin or saline intragastrically once daily for 14 d. Our results showed that treatment with betanin remarkably limited AAA enlargement and mitigated the infiltration of inflammatory cells in the adventitia. The increased expression of proinflammatory cytokines and matrix metalloproteinases (MMPs) was also significantly alleviated following betanin treatment. Furthermore, betanin suppressed the activation of toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-κB) signaling in the aortic wall, and downregulated the levels of tissue-reactive oxygen species as well as circulating 8-isoprostane by stimulating the nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. Taken together, these data suggest that betanin may attenuate AAA progression and may be used as a therapeutic drug against AAA.