Discharge properties of hippocampal neurons during performance of a jump avoidance task.
Discharge properties of hippocampal neurons during performance of a jump avoidance task.
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DOI：
10.1523/jneurosci.5329-07.2008
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发表时间：
2008-07-02
影响因子：
5.3
通讯作者：
Muller, Robert U.
中科院分区：
文献类型：
--
作者：
Lenck-Santini, Pierre-Pascal;Fenton, Andre A.;Muller, Robert U.
我们记录单个海马细胞，而大鼠进行跳跃回避任务。在这项任务中，一只大鼠被扔到一个33厘米的灰色木制立方体的金属地板上，如果它在15秒内没有跳到盒子边缘上，就会受到轻微的电击。我们发现，许多海马锥体细胞和大多数中间神经元放电优先在下降，跳跃或在这两个事件。通过同时记录海马EEG，我们发现大多数事件相关的锥体细胞的放电是由θ节律调制的，而且放电以与锥体细胞作为位置细胞的作用相同的方式随着θ周期进行进动。在下降和跳跃的放电率的海拔是伴随着θ频率的增加。我们的结论是，事件相关放电的许多功能可以被解释为等同于在盒地板以上的发射场的位置细胞的活动。然而，位置细胞的预期和观察到的活动之间存在足够的差异，表明锥体细胞可能能够发出事件和位置的信号。
We recorded single hippocampal cells while rats performed a jump avoidance task. In this task, a rat was dropped onto the metal floor of a 33 cm gray wooden cube and was given a mild electric shock if it did not jump up onto the box rim in less than 15 sec. We found that many hippocampal pyramidal cells and most interneurons discharged preferentially at either the drop, the jump or on both events. By simultaneously recording the hippocampal EEG, we found that the discharge of most of the event-related pyramidal cells was modulated by the theta rhythm and moreover that discharge precessed with theta cycles in the same fashion seen for pyramidal cells in their role as place cells. The elevations of firing rate at drop and jump were accompanied by increases in theta frequency. We conclude that many of the features of event-related discharge can be interpreted as being equivalent to the activity of place cells with firing fields above the box floor. Nevertheless, there are sufficient differences between expectations from place cells and observed activity to indicate that pyramidal cells may be able to signal events as well as location.