Hyaluronic acid skin fillers: Adverse reactions and skin testing
Hyaluronic acid skin fillers: Adverse reactions and skin testing
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DOI：
10.1067/mjd.2001.117381
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发表时间：
2001-12-01
影响因子：
13.8
通讯作者：
Shah, K
中科院分区：
文献类型：
--
作者：
Lowe, NJ;Maxwell, CA;Shah, K
背景：透明质酸（HA）填充物已被提议作为其他临时皮肤填充物的替代品，如牛胶原蛋白，用于治疗面部皮肤线条和提供丰唇。目前在许多国家都有几种类型的商用透明质酸填充剂，包括Restylane，它是由微生物工程技术生产的，Hylaform是从鸡冠中提取的透明质酸。它们已经在几个国家被批准使用，但目前还没有在美国使用。没有建议制造商进行预处理皮肤试验。目的：描述和评价我们使用Hylaform和Restylane填充剂的经验。观察任何副作用和皮肤试验结果记录在案。方法：1996年9月~ 2000年9月，对709例患者进行海拉芬和瑞斯苯胺联合治疗，临床随访1年以上。其中3例(0.42%)出现延迟性皮肤反应。其他三名患者被转诊接受其他医生对其皮肤反应的评估。这6个病人中有5个同意对前臂进行皮肤测试。结果：5例患者中，4例皮内试阳性；这些反应开始于注射后约8周。结论：两种透明质酸填充剂均有轻微的延迟性皮肤炎症反应。这两种反应都发生在第一次注射和重复注射后。5例受试患者中有4例皮肤试验呈阳性。
Background: Hyaluronic acid (HA) fillers have been proposed as alternatives to other temporary skin fillers, such as bovine collagen, for treating facial skin lines and for providing lip augmentation. Several types of commercial HA fillers are now available in many countries, They include Restylane, which is produced by microbiologic engineering techniques, and Hylaform, which is HA extract derived from rooster combs. They have been approved for use in several countries, but not currently in the United States. There are no recommendations to perform pretreatment skin testing by the manufacturers.Objective: Our purpose is to describe and comment oil our experiences with Hylaform and Restylane fillers. Observation of any side effects and skin testing results were documented.Methods: Between September 1996 and September 2000, 709 patients were treated with Hylaform and Restylane and were followed up clinically for at least 1 year. Three of these patients (0.42%) developed delayed skin reactions. Three other patients were referred for evaluation of their skin reactions from other practitioners. Five of these 6 patients agreed to skin testing of their forearms.Results: In the 5 patients tested, challenge intradermal skin testing was positive in 4 patients; the reactions started approximately 8 weeks after injection.Conclusions: There was a slight incidence of delayed inflammatory skin reactions to two HA fillers. Both of these reactions occurred after the first and repeat injections. Challenge skin testing was positive in 4 of 5 tested patients.