Dietary lignan intakes and risk of pre- and postmenopausal breast cancer.
Dietary lignan intakes and risk of pre- and postmenopausal breast cancer.
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膳食木脂素摄入量与绝经前和绝经后乳腺癌的风险。
DOI：
10.1002/ijc.20262
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发表时间：
2004
影响因子：
6.4
通讯作者：
Freudenheim,JoL
中科院分区：
文献类型：
--
作者：
McCann,SusanE;Muti,Paola;Vito,Dominica;Edge,StephenB;Trevisan,Maurizio;Freudenheim,JoL
木脂素是一种植物化合物，在哺乳动物的肠道中代谢产生植物雌激素、肠内酯和肠二醇。由于雌激素与乳腺癌的病因有关，木脂素可能通过调节内源性雌激素代谢或与雌激素受体竞争抑制来影响乳腺癌的风险。作为纽约西部暴露和乳腺癌(Web)研究的一部分，我们在一项基于人群的病例对照研究中检查了乳腺癌风险和饮食木脂素摄入量，该研究涉及1122名患有原发、突发事件、组织学证实的乳腺癌的女性和2036名对照频率与年龄和居住县相匹配的病例。饮食通过自填的104项食物频率问卷进行评估，其他相关数据通过详细的面对面访谈收集。木脂素被表达为膳食前体二异落叶松脂醇和松脂酚之和。调整年龄、总能量和其他乳腺癌危险因素后，通过非条件Logistic回归估计优势比(OR)和95%可信区间(CI)。绝经前妇女饮食中木脂素摄入量最高的四分位数降低了患乳腺癌的风险(OR=0.66；95%CI=0.44-0.98)。未观察到木脂素摄入量与绝经后乳腺癌之间的关联。我们的结果表明，饮食中的木脂素在乳腺癌的病因中可能很重要，尤其是在绝经前的女性中。©2004 Wiley-Liss Inc.
Lignans are plant compounds metabolized in the mammalian gut to produce the phytoestrogens enterolactone and enterodiol. Because estrogens have been linked to breast cancer etiology, lignans could affect breast cancer risk through modulation of endogenous estrogen metabolism or competitive inhibition with estrogen receptors. We examined breast cancer risk and dietary lignan intake in a population‐based case‐control study of 1,122 women with primary, incident, histologically confirmed breast cancer and 2,036 controls frequency matched to cases on age and county of residence as part of the Western New York Exposures and Breast Cancer (WEB) Study. Diet was assessed with a self‐administered 104‐item food frequency questionnaire and other relevant data were collected by detailed in‐person interviews. Lignans were expressed as the sum of the dietary precursors secoisolariciresinol and matairesinol. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression, adjusting for age, total energy and other breast cancer risk factors. Premenopausal women in the highest quartile of dietary lignan intake had reduced breast cancer risk (OR = 0.66; 95% CI = 0.44–0.98). No association was observed between lignan intakes and postmenopausal breast cancer. Our results suggest that dietary lignans may be important in the etiology of breast cancer, particularly among premenopausal women. © 2004 Wiley‐Liss, Inc.