MORPHOMETRIC COMPARISONS OF OPTIC-NERVE AXON LOSS IN ACQUIRED-IMMUNODEFICIENCY-SYNDROME
MORPHOMETRIC COMPARISONS OF OPTIC-NERVE AXON LOSS IN ACQUIRED-IMMUNODEFICIENCY-SYNDROME
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DOI：
10.1016/s0002-9394(14)75746-0
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发表时间：
1992-01-15
影响因子：
4.2
通讯作者：
SADUN, AA
中科院分区：
文献类型：
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作者：
TENHULA, WN;XU, S;SADUN, AA
视神经的轴突变性和轴突群的减少在衰老和各种神经眼疾病中都有记载。我们应用形态测量技术对获得性免疫缺陷综合征患者的视神经进行尸检。12条视神经（8条来自艾滋病患者，4条来自年龄匹配的对照眼）用对苯二胺染色，并用计算机辅助成像和测量系统进行形态计量学分析。变性往往是严重的，并分散在所有受艾滋病影响的视神经。在艾滋病影响的视神经中，平均轴突数量明显低于正常视神经的平均值（88万个vs 150万个）。尽管轴突损失了大约40%，但平均轴突直径并没有显著差异，这表明没有特定类型的轴突特别容易受到艾滋病相关变性的影响。艾滋病患者视神经轴突丧失的程度和模式表明，这些变化可能不仅是继发于视网膜损伤，而且可能反映了艾滋病相关的原发性视神经病变。
Axonal degeneration and diminution of the axonal population in the optic nerve have been documented in aging and in various neuro-ophthalmic conditions. We applied morphometric techniques to the postmortem examination of optic nerves obtained from patients with acquired immunodeficiency syndrome. Twelve optic nerves (eight from patients with AIDS and four from age-matched control eyes) were stained with paraphenylenediamine and morphometrically analyzed with a computer-assisted image and measurement system. Degeneration was often severe and was scattered throughout all of the AIDS-affected optic nerves. In the AIDS-affected optic nerves, the mean axonal population was markedly lower than the mean obtained from normal optic nerves (880,000 vs 1,507,000). Despite the approximate 40% loss of axons, mean axonal diameters were not markedly different, suggesting that no particular class of axon was especially susceptible to AIDS-associated degeneration. The extent and pattern of axonal loss in optic nerves of patients with AIDS suggest that the changes may not only be secondary to damage at the retina, but may reflect an AIDS-associated primary optic neuropathy.