Justifying the "folate trap" in folic acid fortification programs
Justifying the "folate trap" in folic acid fortification programs
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DOI：
10.1515/jpm.2007.056
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Gaikwad, Nilima L.
中科院分区：
文献类型：
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作者：
Mahajan, Niraj N.;Mahajan, Kshitija N.;Gaikwad, Nilima L.
许多国家现已采取强化措施，将叶酸添加到面粉中，旨在通过提高血液叶酸水平使所有人受益。在叶酸从一种形式向另一种形式的多次转化过程中，一部分会意外转化为 N-5-甲基-THF，一种无活性的代谢物，即所谓的“叶酸陷阱”。应考虑将 B-12 以及叶酸纳入任何补充剂或食品强化计划中，以预防 NTD。这尤其适用于像印度这样的发展中国家，那里的大多数女性都是素食主义者，维生素 B-12 的含量处于临界水平。在改善叶酸状态方面，[6S]-5-MTHF 的施用比叶酸补充剂更有效。因此，我们敦促重新考虑叶酸强化计划中的“叶酸陷阱”。
Many countries have now adopted fortification, where folic acid is added to flour and intended to benefit all with rise in blood folate level. During many transformations of folate from one form to another, a proportion is accidentally converted to N-5-methyl-THF, an inactive metabolite, the so-called "folate trap". Consideration should be given to including B-12 as well as folic acid in any program of supplementation or food fortification to prevent NTDs. This is especially applicable to developing countries like India where the majority of women are vegetarians and have borderline levels of vitamin B-12. Administration of [6S]-5-MTHF is more effective than is folic acid supplementation at improving folate status. Therefore, we urge to reconsider the "folate trap" in folic acid fortification programs.