Mechanisms of cell adhesion in the nervous system: role of the immunoglobulin gene superfamily.
Mechanisms of cell adhesion in the nervous system: role of the immunoglobulin gene superfamily.
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DOI：
10.1159/000111914
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发表时间：
1989
影响因子：
2.9
通讯作者：
J. Salzer;D. Colman
中科院分区：
文献类型：
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作者：
J. Salzer;D. Colman
已知在神经系统中介导细胞-细胞相互作用的大量细胞表面蛋白的氨基酸序列最近已被报道。这些蛋白质中的许多是免疫球蛋白基因超家族的成员，并且在它们的胞外区段中具有非常相似的结构和氨基酸序列。我们将这个免疫球蛋白相关细胞粘附分子家族称为Ig-CAM。在这篇文章中，我们回顾了Ig-CAMs的结构特征，讨论了这些特征如何与这些蛋白质在介导细胞粘附和细胞信号事件中的作用有关，最后考虑了这个蛋白质家族的进化起源。
The amino acid sequences of a large number of the cell surface proteins known to mediate cell-cell interactions in the nervous system have recently been reported. Many of these proteins are members of the immunoglobulin gene superfamily and have remarkably similar structures and amino acid sequences in their extracellular segments. We have termed this family of immunoglobulin-related cell adhesion molecules the Ig-CAMs. In this article, we review the structural features of the Ig-CAMs, discuss how these features may relate to the role of these proteins in mediating cell adhesion and cell signaling events, and finally consider the evolutionary origins of this family of proteins.