Genome-wide differential expression profiling of mRNAs and lncRNAs associated with prolificacy in Hu sheep
Genome-wide differential expression profiling of mRNAs and lncRNAs associated with prolificacy in Hu sheep
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DOI：
10.1042/bsr20171350
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发表时间：
2018-04-27
影响因子：
4
通讯作者：
Zhang, Yanli
中科院分区：
文献类型：
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作者：
Feng, Xu;Li, Fengzhe;Zhang, Yanli
繁殖能力，特别是多产性，影响羊的盈利能力。湖羊是我国特有的绵羊品种，具有繁殖力高、性成熟早、常年发情等特点。然而，对湖羊HP的分子机制知之甚少。为了探讨与湖羊多胎性有关的潜在mRNA和长链非编码RNA（lncRNA），本研究以高胎（3胎）和低胎（1胎）湖羊为研究对象，对湖羊卵泡期卵巢的mRNA和lncRNA进行了全基因组分析。HP组血浆LH浓度高于LP组（P
Reproductive ability, especially prolificacy, impacts sheep profitability. Hu sheep, a unique Chinese breed, is recognized for its high prolificacy (HP), early sexual maturity, and year-round estrus. However, little is known about the molecular mechanisms underlying HP in Hu sheep. To explore the potential mRNAs and long non-coding RNAs (lncRNAs) involved in Hu sheep prolificacy, we performed an ovarian genome-wide analysis of mRNAs and lncRNAs during the follicular stage using Hu sheep of HP (litter size = 3; three consecutive lambings) and low prolificacy (LP, litter size = 1; three consecutive lambings). Plasma luteinizing hormone (LH) concentration was higher in the HP group than in the LP group (P