Early effect of dalfampridine in patients with MS: A multi-instrumental approach to better investigate responsiveness
Early effect of dalfampridine in patients with MS: A multi-instrumental approach to better investigate responsiveness
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DOI：
10.1016/j.jns.2016.06.019
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发表时间：
2016-09-15
影响因子：
4.4
通讯作者：
Confalonieri, P.
中科院分区：
文献类型：
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作者：
Brambilla, L.;Sebastiano, D. Rossi;Confalonieri, P.
背景：4-氨基吡啶 (4-AP) 是一种钾通道阻滞剂，能够提高 MS 患者的步行速度，改善节间钾通道暴露的脱髓鞘轴突的动作电位。目的：利用临床、主观、神经生理学和神经放射学工具研究早期 4-AP 效果。方法：临床（定时 25 英尺步行 - T25FW、定时 Up-And-Go-TUG）、主观（MS 步行）在 4-AP 治疗 14 天之前 (T0) 和之后 (T1) 进行了 Scale-12 - MSWS-12）、神经生理学（运动诱发电位 - MEP）和成像（扩散张量成像 - DTI）评估。 MEP 是从双腿的展肌记录的。在 DTI 上进行了基于区域的空间统计 (TBSS)。结果：我们发现 T25FW、TUG、MSWS-12 的 TO 和 T1 之间存在显着差异 (p
Background: 4-aminopyridine (4-AP) is a potassium-channel blocker able to enhance walking speed in MS improving the action potentials of demyelinated axons on which internodal potassium channels are exposed.Objective: to study early 4-AP effect with clinical, subjective, neurophysiological and neuroradiological tools.Methods: Clinical (Timed 25-Foot Walk - T25FW, Timed Up-And-Go- TUG), subjective (MS Walking Scale-12 - MSWS-12), neurophysiological (Motor Evoked Potentials - MEPs) and imaging (Diffusion Tensor Imaging - DTI) evaluations were performed before (TO) and after (T1) 14 days of 4-AP treatment. MEPs were recorded from Abductor Hallucis of both legs. A Tract-Based-Spatial-Statistics (TBSS) was performed on DTI.Results: We found a significant difference between TO and T1 for T25FW, TUG, MSWS-12 (p