OXYTOCIN ANTAGONISTS DELAY THE INITIATION OF PARTURITION AND PROLONG ITS ACTIVE PHASE IN RATS
OXYTOCIN ANTAGONISTS DELAY THE INITIATION OF PARTURITION AND PROLONG ITS ACTIVE PHASE IN RATS
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DOI：
10.1677/joe.0.1450097
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发表时间：
1995-04-01
影响因子：
4
通讯作者：
RUSSELL, JA
中科院分区：
文献类型：
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作者：
ANTONIJEVIC, IA;DOUGLAS, AJ;RUSSELL, JA
催产素对分娩的启动和维持的生理重要性是有争议的。我们研究了两种新的缩宫素拮抗剂对大鼠分娩的影响，大鼠在足月前一天植入颈静脉插管。在分娩期间，在第二只幼崽出生后，给予大鼠催产素拮抗剂（OVT 16，n=10，或F382，n=7，30 μ g/kg）或赋形剂（n=10，9），并记录再分娩五只幼崽的时间。其他大鼠在第四只幼崽出生后注射F382（30 μ g/kg，n=7）或溶媒（n=9），并记录再分娩三只幼崽的时间。在另一项实验中，在预期分娩当天，对大鼠重复注射F382（30或60 μ g/kg，n=13，11）或赋形剂（n=32），记录发作时间和分娩进展。在第二只幼崽后给予拮抗剂的大鼠在100 +/- 8 min（F382）和83 +/- 12 min（OVT 16）内分娩下五只幼崽，明显慢于相应的对照组（51 +/- 6和49 +/- 6 min，U检验，P
The physiological importance of oxytocin for the initiation and maintenance of labour and delivery is controversial. We investigated the effects of two novel peptide oxytocin antagonists on the onset and the progress ofdelivery in rats implanted with a jugular vein cannula one day before term. During delivery rats were given either an oxytocin antagonist (OVT16, n=10, or F382, n=7, 30 mu g/kg) or vehicle (n=10, 9) after the birth of the second pup and the time to deliver five more pups was recorded. Other rats were given an injection of F382 (30 mu g/kg, n=7) or vehicle (n=9) after the birth of the fourth pup and the time to deliver three more pups was recorded. In another experiment rats were given repeated injections of F382 (30 or 60 mu g/kg, n=13, 11) or vehicle (n=32) prepartum on the day of expected term and the time of onset and the progress of delivery was recorded. Rats given an antagonist after the second pup delivered the next five pups in 100 +/- 8 min (F382) and 83 +/- 12 min (OVT16), significantly slower than the respective controls (51 +/- 6 and 49 +/- 6 min, U-test, P