NF-κB as a molecular target in adjuvant therapy of gastrointestinal carcinomas
NF-κB as a molecular target in adjuvant therapy of gastrointestinal carcinomas
复制标题
DOI：
10.1016/j.ejso.2004.10.010
复制
发表时间：
2005-05-01
期刊：
影响因子：
3.8
通讯作者：
Zhu, ZG
中科院分区：
文献类型：
--
作者：
Yu, YY;Li, Q;Zhu, ZG
瞄准描述核因子-κ B（NF-κ B）在癌症治疗中的作用。检索Pubmed数据库，检索词为胃肠癌、NF-κ B B、抑制剂、肿瘤治疗分子靶点、化疗耐药。我们综述了NF-κ B B活化在胃肠道肿瘤化疗耐药、肿瘤生长抑制和细胞凋亡增强中的作用。确定了抑制NF-κ B活化的几种可能的策略。讨论了靶向NF-κ B B作为一种潜在的治疗方法在临床医学中的重要性。(c)2004爱思唯尔有限公司保留所有权利。
Aim. To describe the role of nuclear factor-kappa B (NF-kappa B) in cancer treatment.Methods. We searched the Pubmed database (until Oct, 2004) with the keywords of gastrointestinal carcinoma, NF-kappa B, inhibitor, cancer treatment molecular target and chemoresistance. We reviewed the Literature in the role of NF-kappa B activation in chemoresistance, tumour growth suppression and enhancement of apoptosis in gastrointestinal carcinomas.Conclusions. Several possible strategies for inhibiting NF-kappa B activation are identified. The importance of targeting NF-kappa B as a potential therapeutic approach in clinical medicine was discussed. (c) 2004 Elsevier Ltd. All rights reserved.