Handbook of behavior, food and nutrition
Handbook of behavior, food and nutrition
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DOI：
10.1007/978-0-387-92271-3
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
V. Preedy;R. Watson;Colin R. Martin
中科院分区：
文献类型：
--
作者：
V. Preedy;R. Watson;Colin R. Martin
尽管经过二十多年的深入实证研究，并发现了各种有趣的内分泌、免疫、感染、肌肉和神经异常，但这种称为慢性疲劳综合症（CFS）的疾病的病因和发病机制仍然未知。然而，CFS 文献确实证明了一个共识，即 CFS 可能具有复杂且多因素的病因和发病机制，其中涉及诱发因素、诱发因素和持续因素（White 2004）。 CFS 文献还揭示了大量证据，表明营养和饮食缺乏会导致 CFS 病因学图景。本章对慢性疲劳综合症症状中饮食、免疫系统和大脑功能之间相互作用的研究证据进行了全面而深远的回顾。许多慢性疲劳综合征的研究表明营养缺乏，尤其是必需脂肪酸 (EFA)、B 族维生素和镁，所有这些都与典型的慢性疲劳综合征症状显着重叠，包括失能性疲劳、认知功能障碍、睡眠障碍、肌痛、关节痛、头痛和胃肠道不适。尽管实证研究已经确定了慢性疲劳综合征中这些重要的营养缺乏症，但它们似乎与不良饮食摄入无关，因此假设慢性疲劳综合症中发现的营养缺乏症是疾病过程的结果（Afari 等，2000）。
Despite more than two decades of intensive empirical research and the identification of a variety of interesting endocrine, immune, infectious, muscular and neurological abnormalities, the aetiology and pathogenesis of the disease known as Chronic Fatigue Syndrome (CFS) remains unknown. The CFS literature does however demonstrate a consensus that CFS is likely to have a complex and multifactorial aetiology and pathogenesis which involves predisposing, precipitating and perpetuating factors (White 2004). The CFS literature also reveals substantial evidence to suggest that nutritional and dietary deficiencies contribute to the CFS aetiology picture. This chapter provides a comprehensive and far reaching review of the research evidence on the interactions between diet, the immune system and brain function in the symptom profile of CFS. Many investigations of CFS have indicated nutritional deficiencies especially essential fatty acids (EFA), B vitamins and magnesium all of which overlap significantly with typical CFS symptoms of incapacitating fatigue, cognitive dysfunction, sleep disturbance, myalgia, arthralgia, headache and gastrointestinal upset. Although empirical studies have identified these important nutritional deficiencies in CFS, they do not appear to be linked to poor dietary intake, and as such it is hypothesised that nutritional deficiencies found in CFS are produced as result of the illness process (Afari et al. 2000).